ArticlePlant signaling & behavior2010
Application of the gene dosage balance hypothesis to auxin-related ribosomal mutants in Arabidopsis.
Article in Plant signaling & behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Comprehensive characterisation of IAA inactivation pathways reveals the impact of glycosylation on auxin metabolism and plant development in Arabidopsis.Communications biology · 2026Article
- Extensive genome evolution distinguishes maize within a stable tribe of grasses.bioRxiv : the preprint server for biology · 2025Article
- Ribosome heterogeneity and specialization in development.Wiley interdisciplinary reviews. RNA · 2021Review
- Parallel selection on ecologically relevant gene functions in the transcriptomes of highly diversifying salmonids.BMC genomics · 2019Article
- Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mechanism of cytoplasmic mRNA translation.The arabidopsis book · 2015Article
- Dosage Sensitivity of RPL9 and Concerted Evolution of Ribosomal Protein Genes in Plants.Frontiers in plant science · 2015Article
- Functional innovations of three chronological mesohexaploid Brassica rapa genomes.BMC genomics · 2014Article
- The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant.BMC biology · 2013Article
- Transcriptome analysis reveals crosstalk of responsive genes to multiple abiotic stresses in cotton (Gossypium hirsutum L.).PloS one · 2013Article
- Arabidopsis ribosomal proteins control developmental programs through translational regulation of auxin response factors.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Mutation of the cytosolic ribosomal protein-encoding RPS10B gene affects shoot meristematic function in Arabidopsis.BMC plant biology · 2012Article
- Heterosis.The Plant cell · 2010Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Several proteomic studies in Arabidopsis have shown the presence of heterogeneous ribosomal populations in different tissues. However, the phenotypic consequences of the imbalance of those ribosomal populations, and the regulatory mechanisms activated to control specific ratios between them, have yet to be evaluated. In our previous report, the phenotypic characterization of the ribosomal protein family L4 (RPL4) in Arabidopsis suggests that the maintenance of proper auxin-regulated developmental responses requires the simultaneous presence of RPL4A- and RPL4D-containing ribosomes. Based on the analysis of the compensatory mechanisms within the RPL4 family proteins in the rpl4a and rpl4d backgrounds, we propose the Gene Dosage Balance Hypothesis (GDBH) as a regulatory mechanism for ribosomal complexes in Arabidopsis. By using the concepts of dosage compensation and hierarchy, GDBH is able to explain the severity and specificity of different ribosomal mutant phenotypes associated with the same ribosomal complex.
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