ArticleThe Journal of clinical endocrinology and metabolism2010
Free testosterone levels are associated with mobility limitation and physical performance in community-dwelling men: the Framingham Offspring Study.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Cardiovascular safety in middle-aged and older men under testosterone replacement therapy: a systematic review and meta-analysis.Endocrine · 2026Pooled it
- Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity.The Journal of clinical endocrinology and metabolism · 2018Trial
- Effects of Testosterone Supplementation for 3 Years on Muscle Performance and Physical Function in Older Men.The Journal of clinical endocrinology and metabolism · 2017Trial
- Trial
- Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle performance and physical function in a randomized trial.Menopause (New York, N.Y.) · 2014Trial
- Clinical meaningfulness of the changes in muscle performance and physical function associated with testosterone administration in older men with mobility limitation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Trial
- Adverse events associated with testosterone administration.The New England journal of medicine · 2010Trial
- Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study).Asian journal of andrologyTrial
- Back Muscle Strength Is Associated with Self-Reported Morning-Erection Frequency in Apparently Healthy Japanese Male University Students: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Gender Differences in the Relationship Between Fatigue, Different Types of Physical Activity, Postural Changes, and Sleep Quality in University Students-Part II Analyses from a Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Androgens as the "old age stick" in skeletal muscle.Cell communication and signaling : CCS · 2025Review
- Study protocol: associations between hormonal profile and physical and cognitive functions in middle-aged men-a one-year cohort follow-up study.Frontiers in public health · 2025Article
- Gender Differences in the Relationship between Physical Activity, Postural Characteristics and Non-Specific Low Back Pain in Young Adults.Journal of functional morphology and kinesiology · 2024Article
- Biological sex-related differences in whole-body coordination during standing turns in healthy young adults.Scientific reports · 2023Article
- Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis.BMC nephrology · 2022Observational
- Relationship between Testosterone and Sarcopenia in Older-Adult Men: A Narrative Review.Journal of clinical medicine · 2022Review
- Role of sex hormone-binding globulin in the free hormone hypothesis and the relevance of free testosterone in androgen physiology.Cellular and molecular life sciences : CMLS · 2022Review
- SHBG, Bone Mineral Density, and Physical Function Among Injection Drug Users With and Without HIV and HCV.The Journal of clinical endocrinology and metabolism · 2022Article
- Review
- Sex-Specific Differences in the Effect of Free Testosterone on Sarcopenia Components in Older Adults.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
contextMobility limitation is associated with increased morbidity and mortality. The relationship between circulating testosterone and mobility limitation and physical performance is incompletely understood.
objectiveOur objective was to examine cross-sectional and prospective relations between baseline sex hormones and mobility limitations and physical performance in community-dwelling older men. DESIGN, SETTING, AND
participantsWe conducted cross-sectional and longitudinal analyses of 1445 men (mean age 61.0 +/- 9.5 yr) who attended Framingham Offspring Study examinations 7 and 8 (mean 6.6 yr apart). Total testosterone (TT) was measured by liquid chromatography tandem mass spectrometry at examination 7. Cross-sectional and longitudinal analyses of mobility limitation and physical performance were performed with continuous (per SD) and dichotomized [low TT and free testosterone (FT) and high SHBG vs. normal] hormone levels.
main outcome measuresSelf-reported mobility limitation, subjective health, usual walking speed, and grip strength were assessed at examinations 7 and 8. Short physical performance battery was performed at examination 7.
resultsHigher continuous FT was positively associated with short physical performance battery score (beta = 0.13; P = 0.008), usual walking speed (beta = 0.02; P = 0.048), and lower risk of poor subjective health [odds ratio (OR) = 0.72; P = 0.01]. In prospective analysis, 1 SD increase in baseline FT was associated with lower risk of developing mobility limitation (OR = 0.78; 95% confidence interval = 0.62-0.97) and progression of mobility limitation (OR = 0.75; 95% confidence interval = 0.60-0.93). Men with low baseline FT had 57% higher odds of reporting incident mobility limitation (P = 0.03) and 68% higher odds of worsening of mobility limitation (P = 0.007).
conclusionsLower levels of baseline FT are associated with a greater risk of incident or worsening mobility limitation in community-dwelling older men. Whether this risk can be reduced with testosterone therapy needs to be determined by randomized trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.