ReviewCytokine2010
B cells as under-appreciated mediators of non-auto-immune inflammatory disease.
Review in Cytokine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Insulin use promotes pro-inflammatory changes in the transcriptome of atherosclerotic plaques in patients with diabetes mellitus.Journal of molecular and cellular cardiology plus · 2025Article
- How exosomal platelet-derived miRNAs can lead to spontaneous osteoclastogenesis in osteoporosis: a new mechanistic viewpoint.Frontiers in medicine · 2025Article
- Review
- B cell depletion in patients with rheumatoid arthritis is associated with reduced IL-1β in GCF.Clinical oral investigations · 2022Article
- B-Cell RANKL Contributes to Pathogen-Induced Alveolar Bone Loss in an Experimental Periodontitis Mouse Model.Frontiers in physiology · 2021Article
- Bone-sparing effects of rituximab and body composition analysis in a cohort of postmenopausal women affected by rheumatoid arthritis - retrospective study.Reumatologia · 2021Article
- The Complexity of Microglial Interactions With Innate and Adaptive Immune Cells in Alzheimer's Disease.Frontiers in aging neuroscience · 2020Review
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.International immunopharmacology · 2018Review
- Obesity, Fat Mass and Immune System: Role for Leptin.Frontiers in physiology · 2018Review
- Obesity induces pro-inflammatory B cells and impairs B cell function in old mice.Mechanisms of ageing and development · 2017Article
- Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.PloS one · 2017Article
- Ageing and obesity similarly impair antibody responses.Clinical and experimental immunology · 2017Review
- Adipose Tissue Inflammation Induces B Cell Inflammation and Decreases B Cell Function in Aging.Frontiers in immunology · 2017Review
- Beyond Antibodies: B Cells and the OPG/RANK-RANKL Pathway in Health, Non-HIV Disease and HIV-Induced Bone Loss.Frontiers in immunology · 2017Review
- The impact of bariatric surgery on inflammation: quenching the fire of obesity?Current opinion in endocrinology, diabetes, and obesity · 2016Review
- Obesity decreases B cell responses in young and elderly individuals.Obesity (Silver Spring, Md.) · 2016Article
- Inflammaging decreases adaptive and innate immune responses in mice and humans.Biogerontology · 2016Review
- Vitamin D3 Suppresses Class II Invariant Chain Peptide Expression on Activated B-Lymphocytes: A Plausible Mechanism for Downregulation of Acute Inflammatory Conditions.Journal of nutrition and metabolism · 2016Article
- B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation.Journal of leukocyte biology · 2014Article
- A role for TLR signaling during B cell activation in antiretroviral-treated HIV individuals.AIDS research and human retroviruses · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
B lymphocytes play roles in many auto-immune diseases characterized by unresolved inflammation, and B cell ablation is proving to be a relatively safe, effective treatment for such diseases. B cells function, in part, as important sources of regulatory cytokines in auto-immune disease, but B cell cytokines also play roles in other non-auto-immune inflammatory diseases. B cell ablation may therefore benefit inflammatory disease patients in addition to its demonstrated efficacy in auto-immune disease. Current ablation drugs clear both pro- and anti-inflammatory B cell subsets, which may unexpectedly exacerbate some pathologies. This possibility argues that a more thorough understanding of B cell function in human inflammatory disease is required to safely harness the clinical promise of B cell ablation. Type 2 diabetes (T2D) and periodontal disease (PD) are two inflammatory diseases characterized by little autoimmunity. These diseases are linked by coincident presentation and alterations in toll-like receptor (TLR)-dependent B cell cytokine production, which may identify B cell ablation as a new therapy for co-affected individuals. Further analysis of the role B cells and B cell cytokines play in T2D, PD and other inflammatory diseases is required to justify testing B cell depletion therapies on a broader range of patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.