ArticleTrends in cell biology2010
RNA: state memory and mediator of cellular phenotype.
Article in Trends in cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- The Role of Cells in Encoding and Storing Information: A Narrative Review of Cellular Memory.Cureus · 2024Review
- Single cell phototransfection of mRNAs encoding SARS-CoV2 spike and nucleocapsid into human astrocytes results in RNA dependent translation interference.Frontiers in drug delivery · 2024Article
- Transcript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer.Communications biology · 2021Article
- Article
- A Single Cell but Many Different Transcripts: A Journey into the World of Long Non-Coding RNAs.International journal of molecular sciences · 2020Review
- Investigating the Effects of Brainstem Neuronal Adaptation on Cardiovascular Homeostasis.Frontiers in neuroscience · 2020Article
- Avian Primordial Germ Cells Contribute to and Interact With the Extracellular Matrix During Early Migration.Frontiers in cell and developmental biology · 2019Article
- Translation acrobatics: how cancer cells exploit alternate modes of translational initiation.EMBO reports · 2018Review
- The Human Cell Atlas.eLife · 2017Article
- Single cell transcriptomics of noncoding RNAs and their cell-specificity.Wiley interdisciplinary reviews. RNA · 2017Review
- Challenges and emerging directions in single-cell analysis.Genome biology · 2017Review
- Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Cellular Deconstruction: Finding Meaning in Individual Cell Variation.Trends in cell biology · 2015Review
- Deep sequencing reveals cell-type-specific patterns of single-cell transcriptome variation.Genome biology · 2015Article
- Ribonucleic acid (RNA) biosynthesis in human cancer.Cancer cell international · 2015Article
- Eusocial insects as emerging models for behavioural epigenetics.Nature reviews. Genetics · 2014Review
- Inputs drive cell phenotype variability.Genome research · 2014Article
- The promise of single-cell sequencing.Nature methods · 2014Article
- Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs.Aging cell · 2013Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
It has become increasingly clear that the genome is dynamic and exquisitely sensitive, changing expression patterns in response to age, environmental stimuli and pharmacological and physiological manipulations. Similarly, cellular phenotype, traditionally viewed as a stable end-state, should be viewed as versatile and changeable. The phenotype of a cell is better defined as a 'homeostatic phenotype' implying plasticity resulting from a dynamically changing yet characteristic pattern of gene/protein expression. A stable change in phenotype is the result of the movement of a cell between different multidimensional identity spaces. Here, we describe a key driver of this transition and the stabilizer of phenotype: the relative abundances of the cellular RNAs. We argue that the quantitative state of RNA can be likened to a state memory, that when transferred between cells, alters the phenotype in a predictable manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.