ArticleExperimental cell research2010
Endosomal recycling regulates Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8-dependent cell spreading.
Article in Experimental cell research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder.Scientific reports · 2024Article
- Elevated expression ofFrontiers in molecular biosciences · 2024Article
- Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance.EMBO reports · 2022Article
- N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.Medical oncology (Northwood, London, England) · 2021Article
- The motif EThe Journal of biological chemistry · 2020Article
- Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.American journal of translational research · 2020Article
- Converging physiological roles of the anthrax toxin receptors.F1000Research · 2019Review
- Article
- TEM8 functions as a receptor for uPA and mediates uPA-stimulated EGFR phosphorylation.Cell communication and signaling : CCS · 2018Article
- Down-regulation of tumor endothelial marker 8 suppresses cell proliferation mediated by ERK1/2 activity.Scientific reports · 2016Article
- Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology.PloS one · 2014Article
- Mutations in ANTXR1 cause GAPO syndrome.American journal of human genetics · 2013Article
- The intracellular trafficking pathway of transferrin.Biochimica et biophysica acta · 2012Review
- Article
- Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy.Frontiers in bioscience (Landmark edition) · 2011Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mechanisms for receptor-mediated anthrax toxin internalization and delivery to the cytosol are well understood. However, far less is known about the fate followed by anthrax toxin receptors prior and after cell exposure to the toxin. We report that Anthrax Toxin Receptor 1/Tumor Endothelial Marker 8 (TEM8) localized at steady state in Rab11a-positive and transferrin receptor-containing recycling endosomes. TEM8 followed a slow constitutive recycling route of approximately 30min as determined by pulsed surface biotinylation and chase experiments. A Rab11a dominant negative mutant and Myosin Vb tail expression impaired TEM8 recycling by sequestering TEM8 in intracellular compartments. Sequestration of TEM8 in intracellular compartments with monensin coincided with increased TEM8 association with a multi-protein complex isolated with antibodies against transferrin receptor. Addition of the cell-binding component of anthrax toxin, Protective Antigen, reduced TEM8 half-life from 7 to 3 hours, without preventing receptor recycling. Pharmacological and molecular perturbation of recycling endosome function using monensin, dominant negative Rab11a, or myosin Vb tail, reduced PA binding efficiency and TEM8-dependent cell spreading on PA-coated surfaces without affecting toxin delivery to the cytosol. These results indicate that the intracellular fate of TEM8 differentially affect its cell adhesion and cell intoxication functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.