ArticleTrends in endocrinology and metabolism: TEM2010
Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasis.
Article in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Increased TGF-β/Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus.Molecular metabolism · 2026Article
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- Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids.Developmental cell · 2025Article
- Triphenyl Phosphate Alters Methyltransferase Expression and Induces Genome-Wide Aberrant DNA Methylation in Zebrafish Larvae.Chemical research in toxicology · 2024Article
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- The role of hepatokines in NAFLD.Cell metabolism · 2023Review
- Type 1 diabetes and engineering enhanced islet transplantation.Advanced drug delivery reviews · 2022Review
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- A Multicellular Network Mechanism for Temperature-Robust Food Sensing.Cell reports · 2020Article
- Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling.Cell death & disease · 2020Article
- Transgenerational effects of maternal bisphenol: a exposure on offspring metabolic health.Journal of developmental origins of health and disease · 2019Article
- Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells.Cell metabolism · 2019Article
- Advances in drug discovery for human beta cell regeneration.Diabetologia · 2018Review
- Inactivating hepatic follistatin alleviates hyperglycemia.Nature medicine · 2018Article
- System Level Meta-analysis of Microarray Datasets for Elucidation of Diabetes Mellitus Pathobiology.Current genomics · 2017Article
- Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration.American journal of physiology. Endocrinology and metabolism · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Loss of functional beta-cells is the primary cause of type 2 diabetes, so that there is an acute need to understand how beta-cell number and function are regulated in the adult under normal physiological conditions. Recent studies suggest that members of the transforming growth factor (TGF)-beta family regulate beta-cell function and glucose homeostasis. These factors are also likely to influence beta-cell proliferation and/or the incorporation of new beta-cells from progenitors in adults. Soluble TGFbeta antagonists also appear to have important roles in maintaining homeostasis, and the coordinated activity of TGFbeta family members is likely to regulate the differentiation and function of adult beta-cells, raising the possibility of developing new diabetes therapies based on TGFbeta agonists or antagonists.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.