Evidence map›Paper›PMID 20381870›Full record

Trial reportOphthalmology2010

Progression of geographic atrophy and genotype in age-related macular degeneration.

Michael L Klein, Frederick L Ferris, Peter J Francis, Anne S Lindblad, Emily Y Chew, Sara C Hamon, Jurg Ott

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ophthalmology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Michael L KleinMacular Degeneration Center, Casey Eye Institute, Oregon Health & Science University, and Devers Eye Institute, Portland, Oregon 97239, USA. kleinm@ohsu.edu
Frederick L Ferris
Peter J Francis
Anne S Lindblad
Emily Y Chew
Sara C Hamon
Jurg Ott
Oregon Health & Science University · USBeijing Institute of Genomics · CNEmmes (United States) · USNational Eye Institute · USNational Institutes of Health · USRockefeller University · US

Funding

GENETICS OF AGE RELATED MACULAR DEGENERATIONR01EY012203 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI KLEIN, MICHAEL L · 1998 to 2007
$2.4M
Age-Related Eye Disease Follow-up Study (AREDS) Follow-up StudyZIAEY000489 · NEI · NATIONAL EYE INSTITUTE · PI CHEW, EMILY Y · 2009 to 2025
$639k
Intramural NIH HHS Z99 EY999999Intramural NIH HHS ZIA EY000489NEI NIH HHS R01 EY012203NEI NIH HHS R01-EY12203
6 · The paper itself

Abstract

purposeWe sought to determine whether genotype is associated with rate of growth of geographic atrophy (GA) in eyes with age-related macular degeneration (AMD).

designProspective analysis of participants in a randomized controlled clinical trial.

participantsWe included 114 eyes of 114 participants in the Age-Related Eye Disease Study (AREDS).

methodsFundus photographs from AREDS participants with GA from whom a DNA specimen had been obtained and serial photographs had been taken over a minimum of 2 years were evaluated for progression as determined by change in cumulative area of GA. All fundus photographs were scanned, digitized, and centrally graded longitudinally for area of GA. The relationship of GA progression with previously identified genetic variants associated with AMD was assessed.

main outcome measuresGenotype frequencies and change in cumulative area of GA.

resultsThe mean growth rate of GA for the 114 eyes was 1.79 mm(2)/year (range, 0.17-4.76). No association between growth rate and genotype was present for variants in the CFH, C2, C3, APOE, and TLR3 genes. For the single nucleotide polymorphism rs10490924 in LOC387715/ARMS2, there was a significant association of GA growth rate, both adjusted and unadjusted for initial lesion size, with the homozygous risk genotype as compared with the homozygous nonrisk genotype (unadjusted P = 0.002; Bonferroni-corrected P = 0.014) and for allelic association (Bonferroni-corrected P value = 0.011). Analyses of other measures of GA progression (progression to central GA from extrafoveal GA and development of bilateral GA in those initially with unilateral GA) showed no statistically significant association between progression and the LOC387715/ARMS2/HTRA1 genotype.

conclusionsGrowth rates of GA calculated from digitized serial fundus photographs showed no association with variants in the CFH, C2, C3, APOE, or TLR3 genes. There was a nominally significant association with the LOC387715/ARMS2/HTRA1 genotype, although this finding was not supported by analyses of secondary measures of GA progression. Replication in other populations is needed to establish the existence of an association.

Indexed as

AgedAged, 80 and overApolipoproteins EComplement C2Complement C3Complement Factor HDisease ProgressionFemaleGenotypeGeographic AtrophyHumansMacular DegenerationMaleMiddle AgedPolymerase Chain ReactionPolymorphism, Single NucleotideApolipoproteins EARMS2 protein, humanCFH protein, humanComplement C2Complement C3Complement Factor HProteinsTLR3 protein, humanToll-Like Receptor 3

Identifiers

PMID20381870
PMCPMC2904435
OpenAlexW2094753668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.