ReviewCurrent opinion in genetics & development2010
Targeting X chromosomes for repression.
Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 108 citations in OpenAlex.
- Condensin IDC, DPY-21, and CEC-4 maintain X chromosome repression in C. elegans.PLoS genetics · 2025Article
- Dosage compensation evolution in plants: theories, controversies and mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Article
- Chromosome-Level Assembly of theGenetics · 2020Article
- Global chromatin conformation differences in the Drosophila dosage compensated chromosome X.Nature communications · 2019Article
- Immediate Dosage Compensation Is Triggered by the Deletion of Y-Linked Genes in Silene latifolia.Current biology : CB · 2019Article
- A specialized condensin complex participates in somatic nuclear maturation inMolecular biology of the cell · 2019Article
- The Role of Xist in X-Chromosome Dosage Compensation.Trends in cell biology · 2018Review
- Sex and death: from cell fate specification to dynamic control of X-chromosome structure and gene expression.Molecular biology of the cell · 2018Article
- Article
- Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Repressive Chromatin inGenetics · 2018Review
- Mechanisms of gene regulation in human embryos and pluripotent stem cells.Development (Cambridge, England) · 2017Review
- Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.Cell · 2017Article
- Mutation ofGenes & development · 2017Article
- Meiosis.WormBook : the online review of C. elegans biology · 2017Review
- A histone H4 lysine 20 methyltransferase couples environmental cues to sensory neuron control of developmental plasticity.Development (Cambridge, England) · 2017Article
- Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome.Genome biology and evolution · 2017Article
- An SMC-like protein binds and regulates Caenorhabditis elegans condensins.PLoS genetics · 2017Article
- Dynamic Control of Chromosome Topology and Gene Expression by a Chromatin Modification.Cold Spring Harbor symposia on quantitative biology · 2017Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Dosage compensation is a chromosome-wide regulatory process that balances X-chromosome gene expression between males and females that have different complements. Recent advances have clarified the molecular nature of the Caenorhabditis elegans sex-determination signal, which tallies X-chromosome number relative to the ploidy and controls both the choice of sexual fate and the process of dosage compensation. Dissecting the sex signal has revealed molecular mechanisms by which small quantitative differences in intracellular signals are translated into dramatically different developmental fates. Recent experiments have also revealed fundamental principles by which C. elegans dosage compensation proteins recognize and bind X chromosomes of XX embryos to reduce gene expression. Dosage compensation proteins function not only in a condensin complex specialized for regulating X-chromosome gene expression, but also in distinct condensin complexes that control other chromosome-wide processes: chromosome segregation and meiotic crossover recombination. The reshuffling of interchangeable molecular parts creates independent machines with similar architecture but distinct biological functions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.