ReviewCurrent opinion in immunology2010
Opposing positive and negative regulation of T cell activity during viral persistence.
Review in Current opinion in immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Immunization of recombinant NS3 protein (protease region) of dengue virus induces high levels of CTLA-4 and apoptosis in splenocytes of BALB/c mice.Virus genes · 2024Article
- Immune checkpoint inhibition: prospects for prevention and therapy of hepatocellular carcinoma.Clinical & translational immunology · 2017Review
- Increased Frequency of BK Virus-Specific Polyfunctional CD8+ T Cells Predict Successful Control of BK Viremia After Kidney Transplantation.Transplantation · 2017Article
- Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence.PLoS pathogens · 2016Article
- Article
- Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection.Immunity · 2015Article
- Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Networking at the level of host immunity: immune cell interactions during persistent viral infections.Cell host & microbe · 2013Review
- Accumulation of splice variants and transcripts in response to PI3K inhibition in T cells.PloS one · 2013Article
- Prolonged persistence of measles virus RNA is characteristic of primary infection dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection.Cell host & microbe · 2012Article
- Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.Journal of virology · 2011Article
- The role of IL-10 in regulating immunity to persistent viral infections.Current topics in microbiology and immunology · 2011Review
- Translating insights from persistent LCMV infection into anti-HIV immunity.Immunologic research · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Vigorous T cell responses are crucial for the control of viral infections. However, in some instances antiviral T cell responses are suppressed resulting in viral persistence. The loss of T cell function is regulated by a variety of host-based immunosuppressive factors that directly inhibit antiviral immunity and prevent viral clearance. Nevertheless, residual levels of T cell activity are actively sustained to exert an important degree of control over persistent virus replication. How T cells are differentially regulated in response to persistent infection and the positive and negative signals that result in these divergent functional responses are just now beginning to come to light. Unraveling this complex dual counter-regulation of T cell responses during persistent virus infection will provide valuable insight toward the development of therapies to overcome immune suppression and stimulate T cell responses to eliminate persistent viral replication. In this review we will highlight this emerging field and discuss the complex interplay between immune-modulatory factors that suppress and sustain antiviral immunity to control and in some instances eliminate persistent viral replication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.