ArticleSchizophrenia research2010
The psychosis risk syndrome and its proposed inclusion in the DSM-V: a risk-benefit analysis.
Article in Schizophrenia research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis.Journal of psychiatry & neuroscience : JPN · 2012Pooled it
- Positive Reframing of Psychosis Risk is Perceived as Less Frightening and Stigmatising Than Negative Framing by Adolescents With and Without Prodromal Symptoms: An Experimental Simulated Feedback Study.Early intervention in psychiatry · 2025Trial
- Positive Reframing of Psychosis Risk Is Seen as More Beneficial and Less Harmful Than Negative Framing by Clinicians: An Experimental Videotaped Simulated Feedback Study.Schizophrenia bulletin · 2025Article
- Attenuated mental symptoms in the general population: first data from the observational cross-sectional ATTENTION study in Greece.CNS spectrums · 2025Observational
- Identification of Psychosis Risk and Diagnosis of First-Episode Psychosis: Advice for Clinicians.Psychology research and behavior management · 2024Review
- Emotional and stigma-related experiences relative to being told one is at risk for psychosis.Schizophrenia research · 2021Article
- A predictive model for conversion to psychosis in clinical high-risk patients.Psychological medicine · 2019Article
- Validation of the Korean Version of the Prodromal Questionnaire-Brief Version in Non-Help-Seeking Individuals.Psychiatry investigation · 2019Article
- Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort.Psychological medicine · 2017Article
- Article
- Ethical and Epidemiological Dimensions of Labeling Psychosis Risk.AMA journal of ethics · 2016Review
- Self-labelling and stigma as predictors of attitudes towards help-seeking among people at risk of psychosis: 1-year follow-up.European archives of psychiatry and clinical neuroscience · 2016Article
- Values and DSM-5: looking at the debate on attenuated psychosis syndrome.BMC medical ethics · 2016Article
- Interpersonal sensitivity and functioning impairment in youth at ultra-high risk for psychosis.European child & adolescent psychiatry · 2016Article
- Relationships of perceived public stigma of mental illness and psychosis-like experiences in a non-clinical population sample.Social psychiatry and psychiatric epidemiology · 2015Article
- Towards indicated prevention of psychosis: using probabilistic assessments of transition risk in psychosis prodrome.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Spontaneous labelling and stigma associated with clinical characteristics of peers 'at-risk' for psychosis.Early intervention in psychiatry · 2014Article
- Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity.Biological psychiatry · 2014Article
- Auditory event-related potentials and α oscillations in the psychosis prodrome: neuronal generator patterns during a novelty oddball task.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2014Article
- The 'at-risk mental state' for psychosis in adolescents: clinical presentation, transition and remission.Child psychiatry and human development · 2014Observational
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3 authors at 3 institutions in 1 country.
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Abstract
The inclusion of a psychosis risk syndrome has been proposed for the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders. The appropriateness of inclusion of this new risk syndrome in the DSM depends on a careful analysis of both anticipated benefits and risks. Purported benefits include early recognition and case identification, and the hypothetical benefit of preventive intervention of psychotic disorders, for which there is as yet no clear evidence base. However, there is a potential for high rates of false positives particularly at the community level given the difficulty in discriminating mild symptoms from normal variants and low base rates of the syndrome in the general population. High false-positive rates in and of themselves are not necessarily problematic if the risk-benefit ratio is significantly favorable, as with screening for cardiovascular risk factors. For the psychosis risk syndrome, by contrast, there are substantial risks, for both stigma and discrimination, and for unnecessary exposure to antipsychotic medications, which make the high false-positive rate associated with the psychosis risk designation particularly problematic. More research is needed to improve the positive predictive value of the psychosis risk syndrome so that it can be considered for inclusion in future editions of the DSM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.