ArticleArchives of oral biology2010
Role of Streptococcus mutans eukaryotic-type serine/threonine protein kinase in interspecies interactions with Streptococcus sanguinis.
Article in Archives of oral biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Article
- Potential Effect of Giant Freshwater Prawn Shell Nano Chitosan in Inhibiting the Development ofInternational journal of dentistry · 2023Article
- Fungi-A Component of the Oral Microbiome Involved in Periodontal Diseases.Advances in experimental medicine and biology · 2022Article
- Protein Tyrosine and Serine/Threonine Phosphorylation in Oral Bacterial Dysbiosis and Bacteria-Host Interaction.Frontiers in cellular and infection microbiology · 2021Review
- Post-translational Modifications in Oral Bacteria and Their Functional Impact.Frontiers in microbiology · 2021Review
- Regulatory circuits controlling Spx levels in Streptococcus mutans.Molecular microbiology · 2020Article
- Random Mutagenesis Applied to Reveal Factors Involved in Oxidative Tolerance and Biofilm Formation in FoodborneFrontiers in microbiology · 2019Article
- Two-component signal transduction systems in oral bacteria.Journal of oral microbiology · 2017Review
- Two-component system VicRK regulates functions associated with establishment of Streptococcus sanguinis in biofilms.Infection and immunity · 2014Article
- Antagonistic effect of protein extracts fromExperimental and therapeutic medicine · 2014Article
- Intercellular communications in multispecies oral microbial communities.Frontiers in microbiology · 2014Review
- Microbial interactions in building of communities.Molecular oral microbiology · 2013Review
- Aspects of eukaryotic-like signaling in Gram-positive cocci: a focus on virulence.Future microbiology · 2011Review
- Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveInterspecies interactions of oral streptococci involve the production and excretion of antimicrobial compounds to compete successfully during colonization. Bacteriocin production by Streptococcus mutans and hydrogen peroxide (H2O2) production by Streptococcus sanguinis have been demonstrated as crucial for the clinical relevant antagonism between both species. A potential target of H2O2 is the cell-envelop of S. mutans. In the present study, the role of cell-envelop associated eukaryotic serine/threonine protein kinase (STPK) in S. mutans during interspecies competition has been investigated.
designAllelic replacement via homologous recombination of the STPK encoding gene with a kanamycin resistant determinant has been constructed. The mutant has been screened for the susceptibility towards cell-envelope stress. A previously developed spotting assay was used to simulate interspecies competition.
resultsThe STPK(-) mutant showed an increased susceptibility towards envelop stress caused by H2O2 and was significantly more inhibited during interspecies competition assays.
conclusionsS. mutans is able to sense antimicrobial compounds excreted by competing species and can potentially adjust the cell-envelop towards an increased resistance.
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