ArticleAmerican journal of human genetics2010
Detecting coevolution through allelic association between physically unlinked loci.
Article in American journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Detecting fitness epistasis in recently admixed populations with genome-wide data.BMC genomics · 2020Pooled it
- SLiM 5: Eco-evolutionary Simulations Across Multiple Chromosomes and Full Genomes.Molecular biology and evolution · 2026Article
- X-LDR: an atlas of linkage disequilibrium across species.Genome biology · 2025Article
- Sexual selection and pseudogenization in primate fertilization.Evolution; international journal of organic evolution · 2025Article
- Recurrent Independent Pseudogenization Events of the Sperm Fertilization Gene ZP3r in Apes and Monkeys.Journal of molecular evolution · 2024Article
- Article
- Signatures of Co-evolution and Co-regulation in the CYP3A and CYP4F Genes in Humans.Genome biology and evolution · 2024Article
- Female-induced selective modification of sperm protein SUMOylation-potential mechanistic insights into the non-random fertilization in humans.Journal of evolutionary biology · 2022Article
- Molecular mechanisms and evolution of fertilization proteins.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2021Review
- Genetic incompatibility of the reproductive partners: an evolutionary perspective on infertility.Human reproduction (Oxford, England) · 2021Article
- A sex-specific evolutionary interaction betweeneLife · 2021Article
- Population-specific long-range linkage disequilibrium in the human genome and its influence on identifying common disease variants.Scientific reports · 2019Article
- Molecular evolution of mammalian genes with epistatic interactions in fertilization.BMC evolutionary biology · 2019Article
- Article
- Independent component analysis of SNPs reflects polygenic risk scores for schizophrenia.Schizophrenia research · 2017Article
- Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome.Genetic epidemiology · 2017Article
- Article
- Coordinated Action of Biological Processes during Embryogenesis Can Cause Genome-Wide Linkage Disequilibrium in the Human Genome and Influence Age-Related Phenotypes.Annals of gerontology and geriatric research · 2016Article
- Recent coselection in human populations revealed by protein-protein interaction network.Genome biology and evolution · 2014Article
- Symbiote transmission and maintenance of extra-genomic associations.Frontiers in microbiology · 2014Article
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3 authors.
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Abstract
Coevolving interacting genes undergo complementary mutations to maintain their interaction. Distinct combinations of alleles in coevolving genes interact differently, conferring varying degrees of fitness. If this fitness differential is adequately large, the resulting selection for allele matching could maintain allelic association, even between physically unlinked loci. Allelic association is often observed in a population with the use of gametic linkage disequilibrium. However, because the coevolving genes are not necessarily in physical linkage, this is not an appropriate measure of coevolution-induced allelic association. Instead, we propose using both composite linkage disequilibrium (CLD) and a measure of association between genotypes, which we call genotype association (GA). Using a simple selective model, we simulated loci and calculated power for tests of CLD and GA, showing that the tests can detect the allelic association expected under realistic selective pressure. We apply CLD and GA tests to the polymorphic, physically unlinked, and putatively coevolving human gamete-recognition genes ZP3 and ZP3R. We observe unusual allelic association, not attributable to population structure, between ZP3 and ZP3R. This study shows that selection for allele matching can drive allelic association between unlinked loci in a contemporary human population, and that selection can be detected with the use of CLD and GA tests. The observation of this selection is surprising, but reasonable in the highly selected system of fertilization. If confirmed, this sort of selection provides an exception to the paradigm of chromosomal independent assortment.
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