ReviewWorld journal of gastroenterology2010
Controlling postoperative ileus by vagal activation.
Review in World journal of gastroenterology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03097900 (Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- The potential for autonomic neuromodulation to reduce perioperative complications and pain: a systematic review and meta-analysis.British journal of anaesthesia · 2022Pooled it
- The effect of Cuminum cyminum on the return of bowel motility after abdominal surgery: a triple-blind randomized clinical trial.BMC complementary medicine and therapies · 2024Trial
- Trial
- Does caffeine enhance bowel recovery after elective colorectal resection? A prospective double-blinded randomized clinical trial.Techniques in coloproctology · 2021Trial
- Nicotine chewing gum for the prevention of postoperative ileus after colorectal surgery: a multicenter, double-blind, randomised, controlled pilot study.International journal of colorectal disease · 2017Trial
- From Formula Composition to Precision Nutrition: Who Benefits, From What, and When?Critical care explorations · 2026Article
- Analysis of intestinal motility function regarding the combined effect of mosapride and trehalose in a paralytic ileus animal model.The Journal of veterinary medical science · 2026Article
- Reconceptualizing regional anesthesia as a systemic modulator: a hypothesis-driven gut-brain axis perspective.Frontiers in neuroscience · 2026Article
- The role of medium-frequency pulsed electrotherapy in patients with postoperative ileus after gynecological surgery.Frontiers in surgery · 2025Article
- Effect of the thumbtack needle on gastrointestinal function recovery after laparoscopic radical gastrectomy for gastric cancer with the concept of enhanced recovery after surgery: a randomized controlled trial.Frontiers in surgery · 2025Article
- Role of intraoperative feeding jejunostomy in esophageal cancer surgery.Journal of cardiothoracic surgery · 2022Article
- Chyme Reinfusion Reducing the Postoperative Complications After Definitive Surgery for Small Intestinal Enteroatmospheric Fistula: A Cohort Study.Frontiers in nutrition · 2022Article
- Effect of Coffee Consumption on Postoperative Ileus after Colorectal Surgery: A Meta-Analysis of Randomized Controlled Trials.Gastroenterology research and practice · 2022Review
- Molecular and cellular mechanisms underlying postoperative paralytic ileus by various immune cell types.Frontiers in pharmacology · 2022Review
- Self-administered succus entericus reinfusion before ileostomy closure improves short-term outcomes.BMC surgery · 2021Article
- Article
- Improved motility in the gastrointestinal tract of a postoperative ileus rat model with ilaprazole.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2021Article
- Enteral enriched nutrition to prevent cognitive dysfunction after surgery; a study in rats.Brain, behavior, & immunity - health · 2021Article
- Early Enteral Nutrition Could Reduce Risk of Recurrent Leakage After Definitive Resection of Anastomotic Leakage After Colorectal Cancer Surgery.World journal of surgery · 2021Article
- Ameliorating Effects and Mechanisms of Intra-Operative Vagal Nerve Stimulation on Postoperative Recovery After Sleeve Gastrectomy in Rats.Obesity surgery · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative ileus is a frequently occurring surgical complication, leading to increased morbidity and hospital stay. Abdominal surgical interventions are known to result in a protracted cessation of bowel movement. Activation of inhibitory neural pathways by nociceptive stimuli leads to an inhibition of propulsive activity, which resolves shortly after closure of the abdomen. The subsequent formation of an inflammatory infiltrate in the muscular layers of the intestine results in a more prolonged phase of ileus. Over the last decade, clinical strategies focusing on reduction of surgical stress and promoting postoperative recovery have improved the course of postoperative ileus. Additionally, recent experimental evidence implicated antiinflammatory interventions, such as vagal stimulation, as potential targets to treat postoperative ileus and reduce the period of intestinal hypomotility. Activation of nicotinic receptors on inflammatory cells by vagal input attenuates inflammation and promotes gastrointestinal motility in experimental models of ileus. A novel physiological intervention to activate this neuroimmune pathway is enteral administration of lipid-rich nutrition. Perioperative administration of lipid-rich nutrition reduced manipulation-induced local inflammation of the intestine and accelerated recovery of bowel movement. The application of safe and easy to use antiinflammatory interventions, together with the current multimodal approach, could reduce postoperative ileus to an absolute minimum and shorten hospital stay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.