ArticleJournal of materials science. Materials in medicine2010
Enhanced osteointegration of orthopaedic implant gradient coating composed of bioactive glass and nanohydroxyapatite.
Article in Journal of materials science. Materials in medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Nanohydroxyapatite and Bioactive Glass Composites in Bone Regeneration: A Systematic Review.Cureus · 2025Review
- Polymeric Composite Thin Films Deposited by Laser Techniques for Antimicrobial Applications-A Short Overview.Polymers · 2025Review
- Frame Coating of Single-Walled Carbon Nanotubes in Collagen on PET Fibers for Artificial Joint Ligaments.International journal of molecular sciences · 2020Article
- Fabrication of Porous Bone Scaffolds Using Alginate and Bioactive Glass.Journal of functional biomaterials · 2019Article
- Coatings as the useful drug delivery system for the prevention of implant-related infections.Journal of orthopaedic surgery and research · 2018Review
- Synergistic intrafibrillar/extrafibrillar mineralization of collagen scaffolds based on a biomimetic strategy to promote the regeneration of bone defects.International journal of nanomedicine · 2016Article
- Repair of bone defect by nano-modified white mineral trioxide aggregates in rabbit: A histopathological study.Medicina oral, patologia oral y cirugia bucal · 2015Article
- Short-term and long-term effects of orthopedic biodegradable implants.Journal of long-term effects of medical implants · 2011Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted histologic and histomorphometric studies to evaluate the osteointegration of gradient coatings composed of bioactive glass and nanohydroxyapatite (BG-nHA) on titanium-alloy orthopaedic implants and surrounding bone tissue in vivo. Titanium-alloy implants with a gradient coating (gradient coating group), uncoated implants (uncoated group), and implants with a conventional hydroxyapatite (HA) coating (HA coating group) were randomly implanted in bilateral femoral condyles of 36 male New Zealand rabbits. The bone-implant contact at 12 and 24 weeks and the new bone volume in the notch created for observing bone ingrowth at 4, 12, and 24 weeks were found greater in the gradient coating group than those in both the uncoated group and the HA coating group (p < 0.05). Fluorescence micrographs showed active osteogenesis in the gradient coating group at 4 weeks after implantation. These findings indicated that BG-nHA gradient coatings could enhance the osteointegration of orthopaedic implant.
Indexed as
Identifiers
20379763What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.