ArticleCurrent genetics2010
The choC gene encoding a putative phospholipid methyltransferase is essential for growth and development in Aspergillus nidulans.
Article in Current genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Phosphatidylcholine biosynthesis via ChoC is crucial for cellular integrity and virulence inVirulence · 2026Article
- Phosphatidylcholine levels regulate hyphal elongation and differentiation in the filamentous fungus Aspergillus oryzae.Scientific reports · 2024Article
- Functional, transcriptomic, and lipidomic studies of theMicrobiology spectrum · 2024Article
- Heterogeneous Distribution of Phospholipid Molecular Species in the Surface Culture ofJournal of fungi (Basel, Switzerland) · 2023Article
- Lipid Biosynthesis as an Antifungal Target.Journal of fungi (Basel, Switzerland) · 2018Review
- Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.Virulence · 2018Article
- Regulated Forms of Cell Death in Fungi.Frontiers in microbiology · 2017Review
- Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach.Frontiers in molecular biosciences · 2016Article
- Aspergillus fumigatus flbB encodes two basic leucine zipper domain (bZIP) proteins required for proper asexual development and gliotoxin production.Eukaryotic cell · 2010Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatidylcholines (PCs) are a class of major cell membrane phospholipids that participate in many physiological processes. Three genes, choA, choB and choC, have been proposed to function in the endogenous biosynthesis of PC in Aspergillus nidulans. In this study, we characterize the choC gene encoding a putative highly conserved phospholipid methyltransferase. The previously reported choC3 mutant allele results from a mutation leading to the E177K amino acid substitution. The transcript of choC accumulates at high levels during vegetative growth and early asexual developmental phases. The deletion of choC causes severe impairment of vegetative growth, swelling of hyphal tips and the lack of both asexual and sexual development, suggesting the requirement of ChoC and PC in growth and development. Noticeably, supplementation of the mutant with the penultimate precursor of PC N, N-dimethylaminoethanol leads to full recovery of vegetative growth, but incomplete progression of asexual and sexual development, implying differential roles of PC and its intermediates in fungal growth and development. Importantly, while the choC deletion mutant shows reduced vegetative growth and precocious cell death until day 4, it regains hyphal proliferation and cell viability from day 5, indicating the presence of an alternative route for cellular membrane function in A. nidulans.
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