ReviewJournal of biomedicine & biotechnology2010
Evidence for maternal-fetal genotype incompatibility as a risk factor for schizophrenia.
Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Maternal and Fetal SERPINA3 Polymorphisms and Risk of Preeclampsia: A Dyad and Triad Based Case-Control Study.Current issues in molecular biology · 2025Article
- Fetal programming of schizophrenia: select mechanisms.Neuroscience and biobehavioral reviews · 2015Review
- Entropy-based selection for maternal-fetal genotype incompatibility with application to preterm prelabor rupture of membranes.BMC genetics · 2014Article
- The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research.Social psychiatry and psychiatric epidemiology · 2014Review
- Non-random mating, parent-of-origin, and maternal-fetal incompatibility effects in schizophrenia.Schizophrenia research · 2013Article
- Maternal-fetal blood incompatibility and neuromorphologic anomalies in schizophrenia: Preliminary findings.Progress in neuro-psychopharmacology & biological psychiatry · 2011Article
- Detection of intergenerational genetic effects with application to HLA-B matching as a risk factor for schizophrenia.Human heredity · 2011Article
- Gene-gene interaction in maternal and perinatal research.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal/obstetric complications are implicated in schizophrenia susceptibility. Some complications may arise from maternal-fetal genotype incompatibility, a term used to describe maternal-fetal genotype combinations that produce an adverse prenatal environment. A review of maternal-fetal genotype incompatibility studies suggests that schizophrenia susceptibility is increased by maternal-fetal genotype combinations at the RHD and HLA-B loci. Maternal-fetal genotype combinations at these loci are hypothesized to have an effect on the maternal immune system during pregnancy which can affect fetal neurodevelopment and increase schizophrenia susceptibility. This article reviews maternal-fetal genotype incompatibility studies and schizophrenia and discusses the hypothesized biological role of these ''incompatibility genes". It concludes that research is needed to further elucidate the role of RHD and HLA-B maternal-fetal genotype incompatibility in schizophrenia and to identify other genes that produce an adverse prenatal environment through a maternal-fetal genotype incompatibility mechanism. Efforts to develop more sophisticated study designs and data analysis techniques for modeling maternal-fetal genotype incompatibility effects are warranted.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.