Evidence map›Paper›PMID 20378111›Full record

ReviewFertility and sterility2010

Oocyte maturation failure: a syndrome of bad eggs.

Stephanie Beall, Carol Brenner, James Segars

Abstract readEvaluation StudyReview
In one paragraph

Review in Fertility and sterility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. Review
  3. Is it Permissible to use Human Eggs inAsian bioethics review · 2025
    Article
  4. Article
  5. Article
  6. Novel Genetic Variants inInternational journal of medical sciences · 2025
    Article
  7. Identification of aFrontiers in genetics · 2025
    Article
  8. Review
  9. Article
  10. Advances in the genetic etiology of female infertility.Journal of assisted reproduction and genetics · 2024
    Review
  11. Novel PATL2 variants cause female infertility with oocyte maturation defect.Journal of assisted reproduction and genetics · 2024
    Article
  12. Histories and mysteries underlying meiotic maturation failure in human oocytes.Journal of assisted reproduction and genetics · 2024
    Article
  13. Article
  14. Observational
  15. Early embryonic failure caused by a novel mutation in theWorld journal of clinical cases · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stephanie BeallDepartment of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Carol Brenner
James Segars

Funding

Reproductive Endocrinology And Infertility Clinical Training ProgramZIAHD008737 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SEGARS, JAMES H. · 2009 to 2010
$3.2M
Reproductive Endocrinology And Infertility TrainingZ01HD008737 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI SEGARS, JAMES H. · 2001 to 2008
$2.7M
Characterization of Monkey Embryonic Stem CellsR21RR021881 · NCRR · WAYNE STATE UNIVERSITY · PI BRENNER, CAROL · 2005 to 2007
$578k
Chromosomal anomalies in macaque monkey oocytesR03HD046553 · NICHD · WAYNE STATE UNIVERSITY · PI BRENNER, CAROL · 2005 to 2006
$205k
Intramural NIH HHS Z01 HD008737NCRR NIH HHS R21 RR021881NICHD NIH HHS R03 HD046553
6 · The paper itself

Abstract

To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease.

Indexed as

Reproductive Techniques, AssistedAnimalsCell Culture TechniquesCell DifferentiationFemaleHumansInfertility, FemaleMitosisModels, BiologicalOocytesOogenesisSyndromeTreatment FailureZygote

Identifiers

PMID20378111
PMCPMC2946974

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.