ArticleCost effectiveness and resource allocation : C/E2010
Combining multicriteria decision analysis, ethics and health technology assessment: applying the EVIDEM decision-making framework to growth hormone for Turner syndrome patients.
Article in Cost effectiveness and resource allocation : C/E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 7 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Which Framework to Use? A Systematic Review of Ethical Frameworks for the Screening or Evaluation of Health Technology Innovations.Science and engineering ethics · 2022Pooled it
- Multi-criteria decision analysis for health technology assessment: addressing methodological challenges to improve the state of the art.The European journal of health economics : HEPAC : health economics in prevention and care · 2019Pooled it
- Multicriteria decision analysis (MCDA) in health care: a systematic review of the main characteristics and methodological steps.BMC medical informatics and decision making · 2018Pooled it
- Integrating social justice concerns into economic evaluation for healthcare and public health: A systematic review.Social science & medicine (1982) · 2018Pooled it
- Balancing costs and benefits at different stages of medical innovation: a systematic review of Multi-criteria decision analysis (MCDA).BMC health services research · 2015Pooled it
- 'Real-world' health care priority setting using explicit decision criteria: a systematic review of the literature.BMC health services research · 2015Pooled it
- GrowthHormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome.The Journal of clinical endocrinology and metabolism · 2013Pooled it
- A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome.European journal of endocrinology · 2013Trial
- The Contribution of Dostarlimab to First-Line Treatment of Advanced or Recurrent Endometrial Cancer in Spain: A Multi-Criteria Decision Analysis Approach.Journal of clinical medicine · 2026Article
- Developing the Iranian health insurance benefit optimization model - the IR-HIBOM: a multicriteria decision analysis with decision rules for designing basic health insurance benefit packages.International journal of technology assessment in health care · 2025Article
- Establishment of a value assessment framework for orphan medicinal products in China.Orphanet journal of rare diseases · 2024Article
- Design of a multiple criteria decision analysis framework for prioritizing high-impact health technologies in a regional health service.International journal of technology assessment in health care · 2024Article
- Evaluation of antibody-based preventive alternatives for respiratory syncytial virus: a novel multi-criteria decision analysis framework and assessment of nirsevimab in Spain.BMC infectious diseases · 2024Article
- Synthesis of relevant information around non-core domains to support Multi-Criteria Decision Analysis (MCDA) for decision making.GMS health innovation and technologies · 2024Article
- Should Severity Assessments in Healthcare Priority Setting be Risk- and Time-Sensitive?Health care analysis : HCA : journal of health philosophy and policy · 2023Article
- Efficacy, Safety, and Economics of Innovative Medicines: The Role of Multi-Criteria Decision Analysis and Managed Entry Agreements in Practice and Policy.Frontiers in medical technology · 2021Review
- Early Health Technology Assessment during Nonalcoholic Steatohepatitis Drug Development: A Two-Round, Cross-Country, Multicriteria Decision Analysis.Medical decision making : an international journal of the Society for Medical Decision Making · 2020Article
- A New Decision Model Approach for Health Technology Assessment and A Case Study for Dialysis Alternatives in Turkey.International journal of environmental research and public health · 2020Article
- Using co-creation and multi-criteria decision analysis to close service gaps for underserved populations.Health expectations : an international journal of public participation in health care and health policy · 2019Article
- Moving Towards Accountability for Reasonableness - A Systematic Exploration of the Features of Legitimate Healthcare Coverage Decision-Making Processes Using Rare Diseases and Regenerative Therapies as a Case Study.International journal of health policy and management · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo test and further develop a healthcare policy and clinical decision support framework using growth hormone (GH) for Turner syndrome (TS) as a complex case study.
methodsThe EVIDEM framework was further developed to complement the multicriteria decision analysis (MCDA) Value Matrix, that includes 15 quantifiable components of decision clustered in four domains (quality of evidence, disease, intervention and economics), with a qualitative tool including six ethical and health system-related components of decision. An extensive review of the literature was performed to develop a health technology assessment report (HTA) tailored to each component of decision, and content was validated by experts. A panel of representative stakeholders then estimated the MCDA value of GH for TS in Canada by assigning weights and scores to each MCDA component of decision and then considered the impact of non-quantifiable components of decision.
resultsApplying the framework revealed significant data gaps and the importance of aligning research questions with data needs to truly inform decision. Panelists estimated the value of GH for TS at 41% of maximum value on the MCDA scale, with good agreement at the individual level (retest value 40%; ICC: 0.687) and large variation across panelists. Main contributors to this panel specific value were "Improvement of efficacy", "Disease severity" and "Quality of evidence". Ethical considerations on utility, efficiency and fairness as well as potential misuse of GH had mixed effects on the perceived value of the treatment.
conclusionsThis framework is proposed as a pragmatic step beyond the current cost-effectiveness model, combining HTA, MCDA, values and ethics. It supports systematic consideration of all components of decision and available evidence for greater transparency. Further testing and validation is needed to build up MCDA approaches combined with pragmatic HTA in healthcare decision-making.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.