ArticleCritical care (London, England)2010
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study.
Article in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Recommendations on RBC Transfusion in General Critically Ill Children Based on Hemoglobin and/or Physiologic Thresholds From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2018Guideline
- Pooled it
- Transfusion of older stored blood and risk of death: a meta-analysis.Transfusion · 2012Pooled it
- Trial
- Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2015Trial
- Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial.American journal of respiratory and critical care medicine · 2012Trial
- Evaluation of post-transfusion RBC alloimmunization in dogs using a gel-column crossmatch with and without anti-canine globulin enhancement.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Effect of Deferoxamine on Post-Transfusion Iron, Inflammation, and In Vitro Microbial Growth in a Canine Hemorrhagic Shock Model: A Randomized Controlled Blinded Pilot Study.Veterinary sciences · 2023Article
- Effect of Hypoxic Blood Infusion on Pulmonary Physiology.Frontiers in physiology · 2022Review
- Review
- Age of Red Cells for Transfusion and Outcomes in Critically Ill Patients: A Meta-Analysis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Article
- Risk factors for outcomes of acute respiratory distress syndrome patients: a retrospective study.Journal of thoracic disease · 2019Article
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.Trials · 2018Article
- Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 2.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2017Review
- Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease.Transfusion · 2015Article
- Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children.American journal of hematology · 2015Observational
- Transfusion therapy in paediatric trauma patients: a review of the literature.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Review
- Transfusion of stored red blood cells in trauma patients is not associated with increased procoagulant microparticles.The journal of trauma and acute care surgery · 2014Article
- On the source of the non-transferrin-bound iron which accumulates in packed red blood cell units during storage.Blood transfusion = Trasfusione del sangue · 2014Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTransfusion is a common treatment in pediatric intensive care units (PICUs). Studies in adults suggest that prolonged storage of red blood cell units is associated with worse clinical outcome. No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children.
methodsProspective, observational study conducted in 30 North American centers, in consecutive patients aged <18 years with a stay >or= 48 hours in a PICU. The primary outcome measure was the incidence of multiple organ dysfunction syndrome after transfusion. The secondary outcomes were 28-day mortality and PICU length of stay. Odds ratios were adjusted for gender, age, number of organ dysfunctions at admission, total number of transfusions, and total dose of transfusion, using a multiple logistic regression model.
resultsThe median length of storage was 14 days in 296 patients with documented length of storage. For patients receiving blood stored >or= 14 days, the adjusted odds ratio for an increased incidence of multiple organ dysfunction syndrome was 1.87 (95% CI 1.04;3.27, P = 0.03). There was also a significant difference in the total PICU length of stay (adjusted median difference +3.7 days, P < 0.001) and no significant change in mortality.
conclusionsIn critically ill children, transfusion of red blood cell units stored for >or= 14 days is independently associated with an increased occurrence of multiple organ dysfunction syndrome and prolonged PICU stay.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.