ArticleInorganic chemistry2010
Controlled protein dimerization through hybrid coordination motifs.
Article in Inorganic chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Pulse Dipolar Electron Paramagnetic Resonance Spectroscopy Reveals Buffer-Modulated Cooperativity of Metal-Templated Protein Dimerization.The journal of physical chemistry letters · 2022Article
- Redox- and metal-directed structural diversification in designed metalloprotein assemblies.Chemical communications (Cambridge, England) · 2022Article
- Molecular Approaches to Protein Dimerization: Opportunities for Supramolecular Chemistry.Frontiers in chemistry · 2022Review
- Protein Assembly by Design.Chemical reviews · 2021Review
- Design of metal-mediated protein assemblies via hydroxamic acid functionalities.Nature protocols · 2021Article
- Dual Control of Peptide Conformation with Light and Metal Coordination.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Functional protein nanostructures: a chemical toolbox.Chemical Society reviews · 2018Review
- Tunable Helicity, Stability and DNA-Binding Properties of Short Peptides with Hybrid Metal Coordination Motifs.Chemical science · 2016Article
- Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker.Nature communications · 2016Article
- Metal-Directed Design of Supramolecular Protein Assemblies.Methods in enzymology · 2016Article
- Domain-swapped cytochromeChemical science · 2015Article
- Functional, metal-based crosslinkers for α-helix induction in short peptides.Chemical science · 2013Article
- Hybrid dynamics simulation engine for metalloproteins.Biophysical journal · 2012Article
- Modular and versatile hybrid coordination motifs on alpha-helical protein surfaces.Inorganic chemistry · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Protein homodimerization is the simplest form of oligomerization that is frequently utilized for the construction of functional biological assemblies and the regulation of cellular pathways. Despite its simplicity, dimerization still poses an enormous challenge for protein engineering and chemical manipulation, owing to the large molecular surfaces involved in this process. We report here the construction of a hybrid coordination motif--consisting of a natural (His) and a non-natural ligand (quinolate)--on the alpha-helical surface of cytochrome cb(562), which (a) simultaneously binds divalent metals with high affinity, (b) leads to a metal-induced increase in global protein stability, and importantly, (c) enables the formation of a discrete protein dimer, whose shape is dictated by the inner-sphere metal coordination geometry and closely approximates that of the DNA-binding domains of bZIP family transcription factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.