Evidence map›Paper›PMID 20376613›Full record

ReviewCurrent topics in microbiology and immunology2010

Adenovirus.

Jason G Smith, Christopher M Wiethoff, Phoebe L Stewart, Glen R Nemerow

Registry-linked trialAbstract readReview
In one paragraph

Review in Current topics in microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03325517 (Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics), which is not on this map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03325517 unknown statusnot on this mapstarted 2017, after this paper: background citation

Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics

TypeobservationalSponsorHeba Momen kamelRan2017 to 2019Enrolled50ConditionsAdenovirus
3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
  2. Viral interference of nucleocytoplasmic transport.The Journal of biological chemistry · 2025
    Review
  3. Four decades of adenovirus gene transfer vectors: History and current use.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Frontiers in microbiology · 2022
    Review
  10. Article
  11. High-Capacity Adenoviral Vectors: Expanding the Scope of Gene Therapy.International journal of molecular sciences · 2020
    Review
  12. Article
  13. Review
  14. Journal of virology · 2018
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jason G SmithDepartment of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Christopher M Wiethoff
Phoebe L Stewart
Glen R Nemerow

Funding

AV INTEGRINS AND ADENOVIRUS INTERNALIZATIONR01HL054352 · NHLBI · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 1995 to 2016
$7.5M
ROLE OF CELL INTEGRINS IN ADENOVIRAL CONJUNCTIVITISR01EY011431 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI NEMEROW, GLEN R · 1997 to 2012
$4.9M
NEI NIH HHS R01 EY011431NHLBI NIH HHS R01 HL054352
6 · The paper itself

Abstract

Of the 53 different human adenovirus (HAdV) serotypes belonging to species A-G, a significant number are associated with acute respiratory, gastrointestinal and ocular infections. Replication-defective HAdV-5-based vectors also continue to play a significant role in gene transfer trials and in vaccine delivery efforts in the clinic. Although significant progress has been made from studies of AdV biology, we still have an incomplete understanding of AdV's structure as well as its multifactorial interactions with the host. Continuing efforts to improve knowledge in these areas, as discussed in this chapter, will be crucial for revealing the mechanisms of AdV pathogenesis and for allowing optimal use of AdV vectors for biomedical applications.

Indexed as

Virus InternalizationAdenoviridaeAnimalsCapsidHumansHydrogen-Ion ConcentrationImmune SystemReceptors, VirusVirionVirus AttachmentReceptors, Virus

Identifiers

PMID20376613
PMCPMC3093298

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.