ArticleMycopathologia2010
Truncated Afyap1 attenuates antifungal susceptibility of Aspergillus fumigatus to voriconazole and confers adaptation of the fungus to oxidative stress.
Article in Mycopathologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans.PLoS biology · 2026Article
- The Oxidative Stress Response Highly Depends on Glucose and Iron Availability inJournal of fungi (Basel, Switzerland) · 2024Article
- Genome-Wide Association Analysis for Triazole Resistance inPathogens (Basel, Switzerland) · 2021Article
- Article
- Contributions ofAntimicrobial agents and chemotherapy · 2018Article
- Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2017Article
- Review
- Function of the genetic element 'Mona' associated with fungicide resistance in Monilinia fructicola.Molecular plant pathology · 2017Article
- Transcription factor ADS-4 regulates adaptive responses and resistance to antifungal azole stress.Antimicrobial agents and chemotherapy · 2015Article
- The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back.Journal of microbiology (Seoul, Korea) · 2015Review
- Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance.Fungal genetics and biology : FG & B · 2015Article
- Multiple mechanisms contribute to the development of clinically significant azole resistance in Aspergillus fumigatus.Frontiers in microbiology · 2015Review
- Transcription factor CCG-8 as a new regulator in the adaptation to antifungal azole stress.Antimicrobial agents and chemotherapy · 2014Article
- Multidrug resistance in fungi: regulation of transporter-encoding gene expression.Frontiers in physiology · 2014Review
- Article
- Discovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossing.PloS one · 2012Article
- Regulatory circuitry governing fungal development, drug resistance, and disease.Microbiology and molecular biology reviews : MMBR · 2011Review
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Authors and funding
3 authors.
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Abstract
In yeasts truncated YAP1 homologues confer antifungal resistance. Our previous work has identified Afyap1, a YAP1 homologue, in Aspergillus fumigatus and found that it is responsible for oxidative stress in vitro. In order to decipher whether truncated Afyap1 involves in antifungal resistance mechanism and in oxidative stress adaptation in A. fumigatus, we introduce a putatively hyperactive truncated Afyap1 into wild-type A. fumigatus. We found that the resulted A. fumigatus containing truncated Afyap1 attenuated susceptibility to voriconazole and resistance to various oxidants. However, the Afyap1 deletion mutant and the strain harboring multiple copies of full-length Afyap1 had voriconazole susceptibility comparable with that of a wild-type A. fumigatus strain. Our study demonstrates that the truncated Afyap1 may involve in antifungal resistance to voriconazole in A. fumigatus and that the truncated Afyap1 sufficiently confers tolerance to oxidative stress in A. fumigatus.
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