ReviewMedical microbiology and immunology2010
The role of evolutionarily conserved signalling systems in Echinococcus multilocularis development and host-parasite interaction.
Review in Medical microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- A novel activation-related gene P158 is essential for evagination and early development of Echinococcus multilocularis protoscoleces.Parasites & vectors · 2026Article
- Aptazyme-mediated gene regulation in Strongyloides stercoralis for functional studies of insulin receptor isoform specificity.PLoS pathogens · 2025Article
- Serum osteopontin levels predict short-term outcomes in patients with hepatitis B-related acute-on-chronic liver failure.Journal of virus eradication · 2025Article
- Human Alveolar Echinococcosis-A Neglected Zoonotic Disease Requiring Urgent Attention.International journal of molecular sciences · 2025Review
- Receptor Tyrosine Kinase Signaling InvolvesTropical medicine and infectious disease · 2024Review
- Effect of sunitinib against Echinococcus multilocularis through inhibition of VEGFA-induced angiogenesis.Parasites & vectors · 2023Article
- Resveratrol againstTropical medicine and infectious disease · 2023Article
- Molecular characterization and immunological properties of Echinococcus granulosus sensu stricto (G1) ADK1 and ADK8.Parasitology research · 2023Article
- Percutaneous management in hepatic alveolar echinococcosis: A sum of single center experiences and a brief overview of the literature.World journal of gastrointestinal surgery · 2023Article
- Targeted and non-targeted proteomics to characterize the parasite proteins ofFrontiers in cellular and infection microbiology · 2023Article
- Food-borne zoonotic echinococcosis: A review with special focus on epidemiology.Frontiers in veterinary science · 2022Review
- Natural history ofFrontiers in veterinary science · 2022Article
- EmCyclinD-EmCDK4/6 complex is involved in the host EGF-mediated proliferation ofFrontiers in microbiology · 2022Article
- Expression profile of circular RNAs in cystic echinococcosis pericystic tissue.Journal of clinical laboratory analysis · 2021Article
- In-House Developed ELISA Indicates High Prevalence of Anti-Pathogens (Basel, Switzerland) · 2020Article
- Metformin Suppresses Development of the Echinococcus multilocularis Larval Stage by Targeting the TOR Pathway.Antimicrobial agents and chemotherapy · 2020Article
- Article
- The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis.Food and waterborne parasitology · 2019Article
- Echinococcosis: Advances in the 21st Century.Clinical microbiology reviews · 2019Review
- Effect of anacardic acid against echinococcosis through inhibition of VEGF-induced angiogenesis.Veterinary research · 2019Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar echinococcosis, one of the most serious and life-threatening zoonoses in the world, is caused by the metacestode larval stage of the fox-tapeworm Echinococcus multilocularis. Mostly due to its accessibility to in vitro cultivation, this parasite has recently evolved into an experimental model system to study larval cestode development and associated host-parasite interaction mechanisms. Respective advances include the establishment of axenic in vitro cultivation systems for parasite larvae as well as culture systems by which the early development of metacestode vesicles from totipotent parasite stem cells can be reconstituted under controlled laboratory conditions. A series of evolutionarily conserved signalling molecules of the insulin, epidermal growth factor and transforming growth factor-beta pathways that are able to functionally interact with corresponding host cytokines have been described in E. multilocularis and most likely play a crucial role in parasite development within the liver of the intermediate host. Furthermore, a whole genome sequencing project has been initiated by which a comprehensive picture on E. multilocularis cell-cell communication systems will be available in due time, including information on parasite cytokines that are secreted towards host tissue and thus might affect the immune response. In this article, an overview of our current picture on Echinococcus signalling systems will be given, and the potential to exploit these pathways as targets for anti-parasitic chemotherapy will be discussed.
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Registered trials
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