ArticleImmunogenetics2010
Comparative genomic analysis of mammalian NKG2D ligand family genes provides insights into their origin and evolution.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Inside the supergene of the bird with four sexes.Hormones and behavior · 2020Review
- Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of SVS2 in Male Fertility.International journal of molecular sciences · 2019Article
- Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility.Nature communications · 2018Article
- Conservation of sequence motifs suggests that the nonclassical MHC class I lineages CD1/PROCR and UT were established before the emergence of tetrapod species.Immunogenetics · 2018Article
- Diversity of ULBP5 in Old-World monkeys (Cercopithecidae) and divergence of the ULBP gene family in primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Article
- Anti-NKG2D mAb: A New Treatment for Crohn's Disease?International journal of molecular sciences · 2017Review
- Marsupials and monotremes possess a novel family of MHC class I genes that is lost from the eutherian lineage.BMC genomics · 2015Article
- Divergence and diversity of ULBP2 genes in rhesus and cynomolgus macaques.Immunogenetics · 2014Article
- Exceptionally high conservation of the MHC class I-related gene, MR1, among mammals.Immunogenetics · 2013Article
- Genome of the Chinese tree shrew.Nature communications · 2013Article
- Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Immunogenetics of the NKG2D ligand gene family.Immunogenetics · 2012Review
- ULBP4/RAET1E is highly polymorphic in the Old World monkey.Immunogenetics · 2011Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NKG2D is a major activating receptor of natural killer cells. Its ligands are major histocompatibility complex (MHC) class I-like molecules whose expression is induced by cellular stresses such as infections and tumorigenesis. Humans have two families of NKG2D ligands (NKG2DL): MHC class I-related chains (MIC) encoded in the MHC and UL16-binding proteins (ULBP) encoded outside the MHC. By contrast, mice have only the latter family of ligands; instead, they have non-MHC-encoded MILL molecules that are closely related to MIC, but do not function as NKG2DL. To gain insights into the origin and evolution of MIC, ULBP, and MILL gene families, we conducted comparative genomic analysis of NKG2DL family genes in five mammalian species. In the opossum MHC, we identified a ULBP-like gene adjacent to a previously described MIC-like gene, suggesting that ULBP genes were originally encoded in the MHC. The opossum genome also contained a transcribed MILL-like gene in a region syntenic to the rodent regions encoding MILL molecules. These observations indicate that MIC-, ULBP-, and MILL-like genes emerged before the divergence of placental and marsupial mammals. Comparison of the human, cattle, rat, mouse, and opossum genomes indicates that after emigration from the MHC, ULBP genes underwent extensive duplications in each species. In mice, some of the ULBP genes appear to have been translocated telomerically on the same chromosome, forming a major cluster of existent NKG2DL genes.
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