ArticlePloS one2010
Altered gene synchrony suggests a combined hormone-mediated dysregulated state in major depression.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 47 citations in OpenAlex.
- Spatial transcriptomic analysis of the mouse brain following chronic social defeat stress.Exploration (Beijing, China) · 2023Article
- Identification of major depressive disorder disease-related genes and functional pathways based on system dynamic changes of network connectivity.BMC medical genomics · 2021Article
- Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs.Molecular psychiatry · 2020Article
- Sex-Specific Effects of Stress on Mood-Related Gene Expression.Molecular neuropsychiatry · 2019Article
- Sex differences and the neurobiology of affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Estrogen receptor α drives pro-resilient transcription in mouse models of depression.Nature communications · 2018Article
- A novel relationship for schizophrenia, bipolar and major depressive disorder Part 5: a hint from chromosome 5 high density association screen.American journal of translational research · 2017Article
- Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.Frontiers in systems neuroscience · 2017Article
- Differential Peripheral Proteomic Biosignature of Fluoxetine Response in a Mouse Model of Anxiety/Depression.Frontiers in cellular neuroscience · 2017Article
- Expression of p21-activated kinases 1 and 3 is altered in the brain of subjects with depression.Neuroscience · 2016Article
- Mood, stress and longevity: convergence on ANK3.Molecular psychiatry · 2016Article
- Genetic variants in Alzheimer disease - molecular and brain network approaches.Nature reviews. Neurology · 2016Review
- Article
- Towards understanding and predicting suicidality in women: biomarkers and clinical risk assessment.Molecular psychiatry · 2016Article
- Altered expression of neuroplasticity-related genes in the brain of depressed suicides.Neuroscience · 2015Article
- Sex differences in mood disorders: perspectives from humans and rodent models.Biology of sex differences · 2014Article
- Article
- Beyond modules and hubs: the potential of gene coexpression networks for investigating molecular mechanisms of complex brain disorders.Genes, brain, and behavior · 2014Review
- Sex chromosome complement regulates expression of mood-related genes.Biology of sex differences · 2013Article
- Biological substrates underpinning diagnosis of major depression.The international journal of neuropsychopharmacology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Coordinated gene transcript levels across tissues (denoted "gene synchrony") reflect converging influences of genetic, biochemical and environmental factors; hence they are informative of the biological state of an individual. So could brain gene synchrony also integrate the multiple factors engaged in neuropsychiatric disorders and reveal underlying pathologies? Using bootstrapped Pearson correlation for transcript levels for the same genes across distinct brain areas, we report robust gene transcript synchrony between the amygdala and cingulate cortex in the human postmortem brain of normal control subjects (n = 14; Control/Permutated data, p<0.000001). Coordinated expression was confirmed across distinct prefrontal cortex areas in a separate cohort (n = 19 subjects) and affected different gene sets, potentially reflecting regional network- and function-dependent transcriptional programs. Genewise regional transcript coordination was independent of age-related changes and array technical parameters. Robust shifts in amygdala-cingulate gene synchrony were observed in subjects with major depressive disorder (MDD, denoted here "depression") (n = 14; MDD/Permutated data, p<0.000001), significantly affecting between 100 and 250 individual genes (10-30% false discovery rate). Biological networks and signal transduction pathways corresponding to the identified gene set suggested putative dysregulated functions for several hormone-type factors previously implicated in depression (insulin, interleukin-1, thyroid hormone, estradiol and glucocorticoids; p<0.01 for association with depression-related networks). In summary, we showed that coordinated gene expression across brain areas may represent a novel molecular probe for brain structure/function that is sensitive to disease condition, suggesting the presence of a distinct and integrated hormone-mediated corticolimbic homeostatic, although maladaptive and pathological, state in major depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.