Evidence map›Paper›PMID 20376306›Full record

ReviewJournal of cardiovascular translational research2010

Recent developments and future challenges on imaging for stem cell research.

Yingli Fu, Dorota Kedziorek, Dara L Kraitchman

Abstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Magnetic resonance imaging of transplanted stem cell fate in stroke.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014
    Review
  5. Review
  6. Review
  7. Imaging Cell Therapy for Myocardial Regeneration.Current cardiovascular imaging reports · 2012
    Article
  8. In vivo imaging for stem cell therapy: new developments and future challenges.European journal of nuclear medicine and molecular imaging · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yingli FuRussell H Morgan Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Dorota Kedziorek
Dara L Kraitchman
Johns Hopkins University · US

Funding

X-ray & MR-visible Microencapsulation of Allogeneic Arteriogenic Cell TherapeuticR33HL089029 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRAITCHMAN, DARA L · 2009 to 2011
$2.1M
X-ray & MR-visible Microencapsulation of Allogeneic Arteriogenic Cell TherapeuticR21HL089029 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KRAITCHMAN, DARA L · 2007 to 2008
$814k
NHLBI NIH HHS R21 HL089029NHLBI NIH HHS R21HL89029NHLBI NIH HHS R33 HL089029
6 · The paper itself

Abstract

As clinical trials with stem cells for cardiac regenerative therapy move forward, advances in imaging equipment and technique offer powerful methods to evaluate therapeutic efficacy. Methodologies to label stem cells for tracking continue to expand. Non-invasive imaging offers the potential to better understand the interaction of exogenous stem cells with the host to answer questions such as the best cell type(s), timing of delivery, dose, and delivery route. If successful, these techniques may enable individually tailored dosing of stem cell therapeutics. However, techniques that are suitable for animal models of cardiac disease may have hurdles to clinical translation beyond simple biocompatibility issues. Challenges include the high cost of advanced imaging techniques, applicability in acute ischemic disease, and regulatory approval. In this review, we will cover some new imaging techniques and labeling strategies and assess the obstacles to clinical adoption.

Indexed as

Molecular ImagingStem Cell TransplantationAnimalsContrast MediaGenes, ReporterHeart DiseasesHumansMagnetic Resonance ImagingMyocardiumRadionuclide ImagingRegenerationTomography, X-Ray ComputedTreatment OutcomeContrast MediaCT ImagingMagnetic Resonance ImagingRadionuclide ImagingReporter Gene ImagingStem Cells

Identifiers

PMID20376306
PMCPMC2850077
OpenAlexW2087751836

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.