ReviewKidney international2010
Multigene kinase network, kidney transport, and salt in essential hypertension.
Review in Kidney international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
- The hypertension-based chronic disease model in a primary care setting.International journal of cardiology. Cardiovascular risk and prevention · 2023Article
- Drosophila melanogaster: a simple genetic model of kidney structure, function and disease.Nature reviews. Nephrology · 2022Review
- Claudin-7 Modulates ClInternational journal of molecular sciences · 2019Article
- Mistargeting of a truncated Na-K-2Cl cotransporter in epithelial cells.American journal of physiology. Cell physiology · 2018Article
- DNPEP is not the only peptidase that produces SPAK fragments in kidney.Physiological reports · 2017Article
- Potassium Sensing by Renal Distal Tubules Requires Kir4.1.Journal of the American Society of Nephrology : JASN · 2017Article
- SGK1 regulation by miR-466g in cortical collecting duct cells.American journal of physiology. Renal physiology · 2016Article
- STK39 and WNK1 Are Potential Hypertension Susceptibility Genes in the BELHYPGEN Cohort.Medicine · 2016Observational
- An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.American journal of physiology. Cell physiology · 2016Review
- Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.The Journal of clinical investigation · 2015Article
- Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.Biochemistry · 2015Article
- Integrated compensatory network is activated in the absence of NCC phosphorylation.The Journal of clinical investigation · 2015Article
- Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.American journal of physiology. Renal physiology · 2015Article
- Distal convoluted tubule.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- Interactive contribution of serine/threonine kinase 39 gene multiple polymorphisms to hypertension among northeastern Han Chinese.Scientific reports · 2014Article
- Protein phosphatase 1 inhibitor-1 deficiency reduces phosphorylation of renal NaCl cotransporter and causes arterial hypotension.Journal of the American Society of Nephrology : JASN · 2014Article
- Functional coupling of renal K+ and Na+ handling causes high blood pressure in Na+ replete mice.The Journal of physiology · 2014Article
- The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.Pflugers Archiv : European journal of physiology · 2014Review
- Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function.Current opinion in nephrology and hypertension · 2014Review
- Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Evidence is mounting that a multi-gene kinase network is central to the regulation of renal Na(+) and K(+) excretion and that aberrant signaling through the pathway can result in renal sodium retention and hypertension (HTN). The kinase network minimally includes the Ste20-related proline-alanine-rich kinase (SPAK), the with-no-lysine kinases (WNKs), WNK4 and WNK1, and their effectors, the thiazide-sensitive NaCl cotransporter and the potassium secretory channel, ROMK. Available evidence indicates that the kinase network normally functions as a switch to change the mineralocorticoid hormone response of the kidney to either conserve sodium or excrete potassium, depending on whether aldosterone is induced by a change in dietary sodium or potassium. Recently, common genetic variants in the SPAK gene have been identified as HTN susceptibility factors in the general population, suggesting that altered WNK-SPAK signaling plays an important role in essential HTN. Here, we highlight recent breakthroughs in this emerging field and discuss areas of consensus and uncertainty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.