SynthesisAmerican journal of nephrology2010
Prevention and treatment of acute kidney injury in patients undergoing cardiac surgery: a systematic review.
Synthesis in American journal of nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 68 citations in OpenAlex.
- Preoperative Short-Term Calorie Restriction for Prevention of Acute Kidney Injury After Cardiac Surgery: A Randomized, Controlled, Open-Label, Pilot Trial.Journal of the American Heart Association · 2018Trial
- Steroids In caRdiac Surgery (SIRS) trial: acute kidney injury substudy protocol of an international randomised controlled trial.BMJ open · 2014Trial
- Addition of N-acetyl cysteine to carvedilol decreases the incidence of acute renal injury after cardiac surgery.Clinical cardiology · 2014Trial
- Trial
- Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study.BMC nephrology · 2012Trial
- Pediatric cardiac surgery associated-acute kidney injury: Interleukin 18 as a new biomarker.World journal of nephrology · 2026Article
- Effectiveness of Atrial Natriuretic Peptide in the Treatment of Critically Ill Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- High-Sensitivity Cardiac Troponin, Natriuretic Peptide, and Long-Term Risk of Acute Kidney Injury: The Atherosclerosis Risk in Communities (ARIC) Study.Clinical chemistry · 2021Article
- Effect of anti-C5 antibody on recuperation from ischemia/reperfusion-induced acute kidney injury.Renal failure · 2019Article
- Cardiopulmonary Bypass and AKI: AKI Is Bad, So Let's Get Beyond the Diagnosis.Frontiers in pediatrics · 2019Review
- Epidemiological characteristics of and risk factors for patients with postoperative acute kidney injury: a multicenter prospective study in 30 Chinese intensive care units.International urology and nephrology · 2018Article
- Mesenchymal Stromal Cells for AKI after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2018Article
- Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery.Journal of the American Society of Nephrology : JASN · 2017Article
- AKIpredictor, an online prognostic calculator for acute kidney injury in adult critically ill patients: development, validation and comparison to serum neutrophil gelatinase-associated lipocalin.Intensive care medicine · 2017Article
- Prevention and Treatment of Cardiac Surgery Associated Acute Kidney Injury.Journal of anesthesia and perioperative medicine · 2016Article
- Validating a scoring tool to predict acute kidney injury (AKI) following cardiac surgery.Canadian journal of kidney health and disease · 2015Article
- Predictive models for kidney disease: improving global outcomes (KDIGO) defined acute kidney injury in UK cardiac surgery.Critical care (London, England) · 2014Article
- Association between preoperative statin use and acute kidney injury biomarkers in cardiac surgical procedures.The Annals of thoracic surgery · 2014Article
- Validation of cell-cycle arrest biomarkers for acute kidney injury after pediatric cardiac surgery.PloS one · 2014Article
- Risk factors for endotracheal re-intubation following coronary artery bypass grafting.Journal of cardiothoracic surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundAcute kidney injury (AKI) is common in patients undergoing cardiac surgery and is associated with a high rate of death, long-term sequelae and healthcare costs. We conducted a systematic review of randomized controlled trials for strategies to prevent or treat AKI in cardiac surgery.
methodsWe screened Medline, Scopus, Cochrane Renal Library, and Google Scholar for randomized controlled trails in cardiac surgery for prevention or treatment of AKI in adults.
resultsWe identified 70 studies that contained a total of 5,554 participants published until November 2008. Most studies were small in sample size, were single-center, focused on preventive strategies, and displayed wide variation in AKI definitions. Only 26% were assessed to be of high quality according to the Jadad criteria. The types of strategies with possible protective efficacy were dopaminergic agents, vasodilators, anti-inflammatory agents, and pump/perfusion strategies. When analyzed separately, dopamine and N-acetylcysteine did not reduce the risk for AKI.
conclusionsThis summary of all the literature on prevention and treatment strategies for AKI in cardiac surgery highlights the need for better information. The results advocate large, good-quality, multicenter studies to determine whether promising interventions reliably reduce rates of acute renal replacement therapy and mortality in the cardiac surgery setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.