ArticleInvestigative ophthalmology & visual science2010
Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Herpes simplex virus type-1 ocular infection in thrombospondin-1 deficient C57BL/6J mice.PloS one · 2026Article
- The Role of Adenosine in γδ T-Cell Regulation of Th17 Responses in Experimental Autoimmune Uveitis.Biomolecules · 2023Review
- γδ T Cells Activated in Different Inflammatory Environments Are Functionally Distinct.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Bidirectional Effect of IFN-γ on Th17 Responses in Experimental Autoimmune Uveitis.Frontiers in ophthalmology · 2022Article
- TLR ligand ligation switches adenosine receptor usage of BMDCs leading to augmented Th17 responses in experimental autoimmune uveitis.Current research in immunology · 2022Article
- Augmented Th17-stimulating activity of BMDCs as a result of reciprocal interaction between γδ and dendritic cells.Molecular immunology · 2021Article
- Adenosine receptor ligation tips the uveitogenic Th1 and Th17 balance towards the latter in experimental autoimmune uveitis-induced mouse.Current research in immunology · 2021Article
- Article
- Connection between γδ T-cell- and Adenosine- Mediated Immune Regulation in the Pathogenesis of Experimental Autoimmune Uveitis.Critical reviews in immunology · 2018Review
- Ability of γδ T cells to modulate the Foxp3 T cell response is dependent on adenosine.PloS one · 2018Article
- Respective IL-17A production by γδ T and Th17 cells and its implication in host defense against chlamydial lung infection.Cellular & molecular immunology · 2017Article
- Functional Conversion and Dominance of γδ T Subset in Mouse Experimental Autoimmune Uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Vγ4Frontiers in immunology · 2017Article
- Regulation of Adenosine Deaminase on Induced Mouse Experimental Autoimmune Uveitis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- CD73 Expressed on γδ T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis.PloS one · 2016Article
- A2B adenosine receptor activation switches differentiation of bone marrow cells to a CD11c(+)Gr-1(+) dendritic cell subset that promotes the Th17 response.Immunity, inflammation and disease · 2015Article
- The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU).Cytokine · 2015Article
- Dermal γδ T cells--What have we learned?Cellular immunology · 2015Review
- Article
- Anti-inflammatory or proinflammatory effect of an adenosine receptor agonist on the Th17 autoimmune response is inflammatory environment-dependent.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
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7 authors.
Funding
Abstract
purposeTo characterize the regulatory effect of gammadelta T cells in the activation of IL-17+ uveitogenic T cells.
methodsThe authors administered the gammadelta TCR-specific antibody GL3 to B6 mice before or after antigen immunization and examined Th1- or Th17-polarized T-cell responses. The intensity of Th17 responses was also examined in responder T cells containing varying numbers of gammadelta T cells.
resultsGL3 treatment resulted in varying degrees of depletion of circulating gammadelta T cells, depending on when the antibody was administered. The intensity of the alphabetaTCR+IL-17+, but not the alphabetaTCR+IFN-gamma+, IRBP-specific T-cell responses was correlated to the percentage of gammadelta T cells in the responder T cells. Kinetic studies showed that early IL-17+ T cells were primarily gammadelta T cells, with a later gradual shift to alphabeta T cells. A close association was seen between the intensity of the IL-17+ autoreactive T-cell response and the percentage of gammadelta T cells in the responder T cells. Although a modest increase in gammadelta T cells among the responder T cells promoted the expansion of IL-17+ alphabetaTCR+ T cells, a higher proportion of gammadelta T cells inhibited it.
conclusionsgammadelta T cells are actively involved in the generation of alphabetaTCR+IL-17+ T cells. The number of gammadelta T cells and the alphabeta/gammadelta T-cell ratio in the responder T cells regulate the intensity of the Th17-type autoreactive T-cell response.
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