ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2010
Effect of aging on cardiac function during cold stress in humans.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 52 citations in OpenAlex.
- Effect of whole-body mild-cold exposure on arterial stiffness and central haemodynamics: a randomised, cross-over trial in healthy men and women.European journal of applied physiology · 2013Trial
- Altered coronary vascular control during cold stress in healthy older adults.American journal of physiology. Heart and circulatory physiology · 2012Trial
- Impact of monthly air pollution and weather conditions on cardiorespiratory mortality in Portuguese Metropolitan Areas.Scientific reports · 2025Article
- Cardiovascular responses to heat and cold exposure are altered by preterm birth in guinea pigs.Physiological reports · 2024Article
- Ambient temperature and the occurrence of intradialytic hypotension in patients receiving hemodialysis.Clinical kidney journal · 2024Article
- Moderate whole body heating attenuates the exercise pressor reflex responses in older humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Noninvasive Measurement of Time-Varying Arterial Wall Elastance Using a Single-Frequency Vibration Approach.Sensors (Basel, Switzerland) · 2020Article
- Adaptive changes in physiological and perceptual responses during 10-day heat acclimation training using a water-perfused suit.Journal of physiological anthropology · 2020Article
- Effect of sympathetic autonomic stress from the cold pressor test on left ventricular function in young healthy adults.Physiological reports · 2019Article
- Behavioral thermoregulation in older adults with cardiovascular co-morbidities.Temperature (Austin, Tex.) · 2018Article
- Cardiovascular diseases, cold exposure and exercise.Temperature (Austin, Tex.) · 2018Review
- Baseline aortic pulse wave velocity is associated with central and peripheral pressor responses during the cold pressor test in healthy subjects.Physiological reports · 2017Article
- The influence of the winter North Atlantic Oscillation index on hospital admissions through diseases of the circulatory system in Lisbon, Portugal.International journal of biometeorology · 2017Article
- Sympathetic regulation during thermal stress in human aging and disease.Autonomic neuroscience : basic & clinical · 2016Review
- Sympathetic control of reflex cutaneous vasoconstriction in human aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Muscle sympathetic nerve activity during cold stress and isometric exercise in healthy older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Effects of different cold-air exposure intensities on the risk of cardiovascular disease in healthy and hypertensive rats.International journal of biometeorology · 2014Article
- Effect of healthy aging on renal vascular responses to local cooling and apnea.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Contribution of sympathetic activation to coronary vasodilatation during the cold pressor test in healthy men: effect of ageing.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
To determine whether skin surface cooling increases left ventricular preload and contractility to a greater extent in older compared with young adults we studied 11 young (28 +/- 2 yr; means +/- SE) and 11 older (64 +/- 3 yr) adults during normothermia (35 degrees C water perfused through a tube-lined suit) and cooling (15 degrees C water perfused for 20 min) using standard and tissue Doppler echocardiography. Cooling significantly decreased skin surface temperature in young (Delta2.8 +/- 0.3 degrees C) and older (Delta3.0 +/- 0.3 degrees C) adults and increased rate-pressure product, an index of myocardial oxygen demand, in older (6,932 +/- 445 to 7,622 +/- 499 mmHg x beats/min for normothermia and cooling, respectively), but not young (7,085 +/- 438 to 7,297 +/- 438 mmHg x beats/min) adults. Increases in blood pressure (systolic and mean blood pressure) during cooling were greater (P < 0.05) in older than in young adults. Cooling increased preload in older (left ventricular end-diastolic volume from 106 +/- 7 to 126 +/- 9 ml and left ventricular internal diameter in diastole from 4.69 +/- 0.12 to 4.95 +/- 0.14 cm; both P < 0.01), but not young adults (left ventricular end-diastolic volume from 107 +/- 7 to 111 +/- 7 ml and left ventricular internal diameter in diastole from 4.70 +/- 0.10 to 4.78 +/- 0.10 cm). Indices of left ventricular contractility (ejection fraction, myocardial acceleration during isovolumic contraction, and peak systolic mitral annulus velocity) were unchanged during cooling in both young and older adults. Collectively, these data indicate that cooling increases left ventricular preload, without affecting left ventricular contractility in older but not young adults. Greater increases in preload and afterload during cooling in older adults contribute to greater increases in indices of myocardial oxygen demand and may help explain the increased risk of cardiovascular events in cold weather.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.