ArticleJournal of neurophysiology2010
Properties of GABAergic neurons in the rostral solitary tract nucleus in mice.
Article in Journal of neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- Somatostatin neurons in the rostral nucleus of the solitary tract are functionally heterogeneous.bioRxiv : the preprint server for biology · 2026Article
- Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine.Physiology & behavior · 2025Article
- A method to estimate the cellular composition of the mouse brain from heterogeneous datasets.PLoS computational biology · 2022Article
- Regulation of Rostral Nucleus of the Solitary Tract Responses to Afferent Input by A-type K+ Current.Neuroscience · 2022Article
- Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.Cellular and molecular neurobiology · 2022Review
- Is there a role for GABA in peripheral taste processing.Current opinion in physiology · 2021Article
- Kv4 channel expression and kinetics in GABAergic and non-GABAergic rNST neurons.Journal of neurophysiology · 2020Article
- Extensive Inhibitory Gating of Viscerosensory Signals by a Sparse Network of Somatostatin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract.The Journal of comparative neurology · 2018Article
- A computational analysis of signal fidelity in the rostral nucleus of the solitary tract.Journal of neurophysiology · 2018Article
- GABAergic and glutamatergic neurons in the brain regulate phase II of migrating motor contractions in the Suncus murinus.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2018Article
- Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice.The Journal of comparative neurology · 2017Article
- Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus.Journal of neurophysiology · 2016Article
- P2X2 Receptor Terminal Field Demarcates a "Transition Zone" for Gustatory and Mechanosensory Processing in the Mouse Nucleus Tractus Solitarius.Chemical senses · 2016Article
- Neuropathology in respiratory-related motoneurons in young Pompe (Gaa(-/-)) mice.Respiratory physiology & neurobiology · 2016Article
- Separate functions for responses to oral temperature in thermo-gustatory and trigeminal neurons.Chemical senses · 2016Article
- Optogenetic and pharmacological evidence that somatostatin-GABA neurons are important regulators of parasympathetic outflow to the stomach.The Journal of physiology · 2016Article
- Kv4 channels underlie A-currents with highly variable inactivation time courses but homogeneous other gating properties in the nucleus tractus solitarii.Pflugers Archiv : European journal of physiology · 2015Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The rostral nucleus of the solitary tract (rNST) plays a pivotal role in taste processing. The rNST contains projection neurons and interneurons that differ in morphology and intrinsic membrane properties. Although characteristics of the projection neurons have been detailed, similar information is lacking on the interneurons. We determined the intrinsic properties of the rNST GABAergic interneurons using a transgenic mouse model that expresses enhanced green fluorescent protein under the control of a GAD67 promoter. Glutamic acid decarboxylase-green fluorescent protein (GAD67-GFP) neurons were distributed throughout the rNST but were concentrated in the ventral subdivision with minimal interaction with the terminal field of the afferent input. Furthermore, the density of the GAD67-GFP neurons decreased in more rostral areas of rNST. In whole cell recordings, GAD67-GFP neurons responded with either an initial burst (73%), tonic (18%), or irregular (9%) discharge pattern of action potentials (APs) in response to membrane depolarization. These three groups also differed in passive and AP characteristics. Initial burst neurons had small ovoid or fusiform cell bodies, whereas tonic firing neurons had large multipolar or fusiform cell bodies. Irregular firing neurons had larger spherical soma. Some of the initial burst and tonic firing neurons were also spontaneously active. The GAD67-GFP neurons could also be categorized in subgroups based on colocalization with somatostatin and parvalbumin immunolabeling. Initial burst neurons would transmit the early dynamic portion of the encoded sensory stimuli, whereas tonic firing neurons could respond to both dynamic and static components of the sensory input, suggesting different roles for GAD67-GFP neurons in taste processing.
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