ArticleJournal of clinical microbiology2010
Evaluation of the C.Diff Quik Chek Complete Assay, a new glutamate dehydrogenase and A/B toxin combination lateral flow assay for use in rapid, simple diagnosis of clostridium difficile disease.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Evaluation of three commercial rapid immunoassays for the diagnosis ofMicrobiology spectrum · 2025Article
- Comparative evaluation of the STANDARD M10 and XpertJournal of clinical microbiology · 2024Article
- Misdiagnosis of Clostridioides difficile Infections by Standard-of-Care Specimen Collection and Testing among Hospitalized Adults, Louisville, Kentucky, USA, 2019-2020Emerging infectious diseases · 2023Article
- Rapid Quantification ofAnalytical chemistry · 2022Article
- The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders.Cell death & disease · 2022Review
- Reduction in Health Care Facility-OnsetMayo Clinic proceedings. Innovations, quality & outcomes · 2021Article
- Evaluation of glutamate dehydrogenase (GDH) and toxin A/B rapid tests for Clostridioides (prev. Clostridium) difficile diagnosis in a university hospital in Minas Gerais, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- The impact of an electronic medical record nudge on reducing testing for hospital-onsetInfection control and hospital epidemiology · 2020Article
- Laboratory Tests for the Diagnosis ofClinics in colon and rectal surgery · 2020Review
- Effectiveness of a Two-Step Testing Algorithm for Reliable and Cost-Effective Detection of Clostridium difficile Infection in a Tertiary Care Hospital in Saudi Arabia.Medical sciences (Basel, Switzerland) · 2019Article
- Laboratory diagnosis of Clostridium difficile infection: Comparison of Techlab C. diff Quik Chek Complete, Xpert C. difficile, and multistep algorithmic approach.Journal of clinical laboratory analysis · 2017Article
- Rapid detection of Clostridium difficile toxins and laboratory diagnosis of Clostridium difficile infections.Infection · 2017Review
- Current knowledge on the laboratory diagnosis ofWorld journal of gastroenterology · 2017Review
- Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B.Toxins · 2016Review
- Diagnosing Clostridium difficile-associated diarrhea using enzyme immunoassay: the clinical significance of toxin negativity in glutamate dehydrogenase-positive patients.Infection and drug resistance · 2016Article
- Clostridium difficile infections among adults and children in Mwanza/Tanzania: is it an underappreciated pathogen among immunocompromised patients in sub-Saharan Africa?New microbes and new infections · 2015Article
- The emergence of Clostridium difficile PCR-ribotype 001 in Slovakia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- An agent-based simulation model for Clostridium difficile infection control.Medical decision making : an international journal of the Society for Medical Decision Making · 2015Article
- Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Bacterial GastroenteritisClinical microbiology reviews · 2015Review
- Comparison of GenomEra C. difficile and Xpert C. difficile as confirmatory tests in a multistep algorithm for diagnosis of Clostridium difficile infection.Journal of clinical microbiology · 2015Article
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Abstract
The diagnosis of Clostridium difficile infection continues to be a challenge for many clinical microbiology laboratories. A new lateral flow assay, the C.Diff Quik Chek Complete assay, which tests for the presence of both glutamate dehydrogenase (GDH) and C. difficile toxins A and B, was evaluated for its ability to diagnose C. difficile disease. The results of this assay were compared to those of both PCR and toxigenic culture. The results showed that this assay allows 88% of specimens to be accurately screened as either positive (both tests positive) or negative (both tests negative) for the presence of toxigenic C. difficile in less than 30 min and with minimal hands-on time. Use of a random-access PCR for the analysis of specimens with discrepant results (one test positive and the other negative) allows the easy, rapid, and highly sensitive (100%; 95% confidence interval [CI], 89.6 to 100%) and specific (99.6%; 95% CI, 97.3 to 99.9%) diagnosis of C. difficile disease. The use of this algorithm would save institutional costs, curtail unnecessary isolation days, reduce the nosocomial transmission of disease, and increase the quality of care for patients.
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