Evidence map›Paper›PMID 20375162›Full record

ArticleJournal of virology2010

The crystal structure of D212 from sulfolobus spindle-shaped virus ragged hills reveals a new member of the PD-(D/E)XK nuclease superfamily.

Smita K Menon, Brian J Eilers, Mark J Young, C Martin Lawrence

Abstract read
In one paragraph

Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Cyclic Tetra-Adenylate (cABiomolecules · 2021
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  4. NovelJournal of virology · 2020
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  6. Review
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  8. Article
  9. Molecular biology of fuselloviruses and their satellites.Extremophiles : life under extreme conditions · 2014
    Review
  10. Review
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Smita K MenonThermal Biology Institute, Montana State University, Bozeman, MT 59717, USA.
Brian J Eilers
Mark J Young
C Martin Lawrence
Montana State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Structural studies have made significant contributions to our understanding of Sulfolobus spindle-shaped viruses (Fuselloviridae), an important model system for archaeal viruses. Continuing these efforts, we report the structure of D212 from Sulfolobus spindle-shaped virus Ragged Hills. The overall fold and conservation of active site residues place D212 in the PD-(D/E)XK nuclease superfamily. The greatest structural similarity is found to the archaeal Holliday junction cleavage enzymes, strongly suggesting a role in DNA replication, repair, or recombination. Other roles associated with nuclease activity are also considered.

Indexed as

Multigene FamilyAmino Acid SequenceDeoxyribonucleasesFuselloviridaeMolecular Sequence DataProtein Structure, SecondarySequence AlignmentViral ProteinsDeoxyribonucleasesViral Proteins

Identifiers

PMID20375162
PMCPMC2876643
OpenAlexW2149902614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.