ArticleMolecular biology of the cell2010
Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Review
- MXD3 Promotes Obesity and the Androgen Receptor Signaling Pathway in Gender-Disparity Hepatocarcinogenesis.Cells · 2021Article
- MXD3 as an onco-immunological biomarker encompassing the tumor microenvironment, disease staging, prognoses, and therapeutic responses in multiple cancer types.Computational and structural biotechnology journal · 2021Article
- Expression profiles of the MXD3 gene and association of sequence variants with growth traits in Xianan and Qinchuan cattle.Veterinary medicine and science · 2020Article
- Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells.Blood cells, molecules & diseases · 2015Article
- Focus formation: a cell-based assay to determine the oncogenic potential of a gene.Journal of visualized experiments : JoVE · 2014Article
- Downregulation of Max dimerization protein 3 is involved in decreased visceral adipose tissue by inhibiting adipocyte differentiation in zebrafish and mice.International journal of obesity (2005) · 2014Article
- MXD3 regulation of DAOY cell proliferation dictated by time course of activation.BMC cell biology · 2014Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Immature B cells migrate to the spleen where they differentiate into mature cells. This final maturation step is crucial to enable B cells to become responsive to antigens and to participate in the immune response. Previously, we showed that Id2 acts as a negative regulator of the differentiation of immature B cells occurring in the spleen. Id2 expression has been found to depend on Myc-Max-Mad transcriptional complexes in mammary epithelial cells. Nearly all studies to date have shown that Mad proteins inhibit proliferation, presumably by antagonizing the function of Myc proteins. In the current study, we followed the Mad family members during peripheral B cell differentiation. We show that Mad3 actively regulates B cell differentiation. Our results demonstrate that high expression levels of Mad3 in immature B cells induce Id2 expression, which inhibits transcription of genes essential for B cell differentiation. During their differentiation to mature cells, B cells reduce their Mad3 expression, enabling the maturation process to occur.
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