ArticleAmerican journal of physiology. Renal physiology2010
Evidence that actomyosin cross bridges contribute to "passive" tension in detrusor smooth muscle.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Integrated Opto-Biomechatronics For Single Muscle Fibre Structure-Function Assessment: The MyoRobot 3.0.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reproducibility of smooth muscle mechanical properties in consecutive stretch and activation protocols.Pflugers Archiv : European journal of physiology · 2025Article
- Regulation of bladder dynamic elasticity: a novel method to increase bladder capacity and reduce pressure using pulsatile external compressive exercises in a porcine model.International urology and nephrology · 2021Article
- Biomechanics of the urinary bladder: spontaneous contraction activity and micromotions related to accommodation.International urology and nephrology · 2021Article
- Comparative-fill urodynamics in individuals with and without detrusor overactivity supports a conceptual model for dynamic elasticity regulation.Neurourology and urodynamics · 2020Article
- An external compress-release protocol induces dynamic elasticity in the porcine bladder: A novel technique for the treatment of overactive bladder?Neurourology and urodynamics · 2019Article
- Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis.Scientific reports · 2019Article
- Modeling the influence of acute changes in bladder elasticity on pressure and wall tension during filling.Journal of the mechanical behavior of biomedical materials · 2017Article
- Axon tension regulates fasciculation/defasciculation through the control of axon shaft zippering.eLife · 2017Article
- A pilot study to measure dynamic elasticity of the bladder during urodynamics.Neurourology and urodynamics · 2017Article
- Evidence for a common mechanism for spontaneous rhythmic contraction and myogenic contraction induced by quick stretch in detrusor smooth muscle.Physiological reports · 2013Article
- Rho-kinase mediated cytoskeletal stiffness in skinned smooth muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Adjustable passive stiffness in mouse bladder: regulated by Rho kinase and elevated following partial bladder outlet obstruction.American journal of physiology. Renal physiology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Contraction of detrusor smooth muscle (DSM) at short muscle lengths generates a stiffness component we termed adjustable passive stiffness (APS) that is retained in tissues incubated in a Ca(2+)-free solution, shifts the DSM length-passive tension curve up and to the left, and is softened by muscle strain and release (strain softened). In the present study, we tested the hypothesis that APS is due to slowly cycling actomyosin cross bridges. APS and active tension produced by the stimulus, KCl, displayed similar length dependencies with identical optimum length values. The myosin II inhibitor blebbistatin relaxed active tension maintained during a KCl-induced contraction and the passive tension maintained during stress-relaxation induced by muscle stretch in a Ca(2+)-free solution. Passive tension was attributed to tension maintaining rather than tension developing cross bridges because tension did not recover after a rapid 10% stretch and release as it did during a KCl-induced contraction. APS generated by a KCl-induced contraction in intact tissues was preserved in tissues permeabilized with Triton X-100. Blebbistatin and the actin polymerization inhibitor latrunculin-B reduced the degree of APS generated by a KCl-induced contraction. The degree of APS generated by KCl was inhibited to a greater degree than was the peak KCl-induced tension by rhoA kinase and cyclooxygenase inhibitors. These data support the hypothesis that APS is due to slowly cycling actomyosin cross bridges and suggest that cross bridges may play a novel role in DSM that uniquely serves to ensure proper contractile function over an extreme working length range.
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