Evidence map›Paper›PMID 20374957›Full record

ReviewCell metabolism2010

Transcriptional control of brown fat development.

Shingo Kajimura, Patrick Seale, Bruce M Spiegelman

Abstract readReview
In one paragraph

Review in Cell metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

209 citing papers in PubMed.

  1. Article
  2. Article
  3. Gabpα-Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Adipocyte Browning: A Promising Avenue in Anti-Obesity Therapy.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Pulling the trigger: Noncoding RNAs in white adipose tissue browning.Reviews in endocrine & metabolic disorders · 2024
    Review

149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shingo KajimuraDana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
Patrick Seale
Bruce M Spiegelman

Funding

CONTROL OF ADIPOCYTE GENE EXPRESSION AND PHYSIOLOGYR37DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1996 to 2013
$8.2M
CONTROL OF LIPOGENIC ENZYME SYNTHESIS IN ADIPOCYTESR01DK031405 · NIDDK · DANA-FARBER CANCER INSTITUTE · PI SPIEGELMAN, BRUCE M. · 1986 to 2018
$2.9M
Physiological role of PRDM16 in brown fat development and energy balanceR00DK081605 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI SEALE, PATRICK · 2009 to 2011
$745k
Physiological role of PRDM16 in brown fat development and energy balanceK99DK081605 · NIDDK · DANA-FARBER CANCER INST · PI SEALE, PATRICK · 2008 to 2009
$181k
Engineering Functional Brown Fat with Anti-Obesity PotentialK99DK087853 · NIDDK · DANA-FARBER CANCER INST · PI KAJIMURA, SHINGO · 2010 to 2011
$135k
NIDDK NIH HHS DK081605NIDDK NIH HHS DK31405NIDDK NIH HHS K99 DK081605NIDDK NIH HHS K99 DK087853NIDDK NIH HHS R00 DK081605NIDDK NIH HHS R01 DK031405NIDDK NIH HHS R37 DK031405
6 · The paper itself

Abstract

Deconvoluting the natural pathway of BAT development has defined key molecular events, which enables researchers to manipulate the amount or activity of brown fat. We review recent advances on the transcriptional regulation of BAT development and discuss the emerging questions.

Indexed as

Adipose Tissue, BrownCell DifferentiationDNA-Binding ProteinsForkhead Transcription FactorsGene Expression RegulationHeat-Shock ProteinsHumansModels, BiologicalPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaThermogenesisTranscription FactorsDNA-Binding ProteinsForkhead Transcription FactorsHeat-Shock Proteinsmesenchyme fork head 1 proteinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanPRDM16 protein, humanTranscription Factors

Identifiers

PMID20374957
PMCPMC2857670

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.