ReviewProgress in molecular biology and translational science2009
Progesterone receptor action in leiomyoma and endometrial cancer.
Review in Progress in molecular biology and translational science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Assessing Long-Term Changes in Endometrial Morphology and Functionality in Dairy Cows With Metritis.Reproduction in domestic animals = Zuchthygiene · 2026Article
- Identification of Key Genes Involved in the Occurrence and Development of Endometrial Cancer.International journal of women's health · 2025Article
- The Influence of Race/Ethnicity on the Transcriptomic Landscape of Uterine Fibroids.International journal of molecular sciences · 2023Article
- Progesterone Signaling and Uterine Fibroid Pathogenesis; Molecular Mechanisms and Potential Therapeutics.Cells · 2023Review
- Possible significance of degeneration and decreased expression of progesterone receptor in postmenopausal uterine leiomyoma.BMC women's health · 2022Article
- Uterine fibroids - Causes, impact, treatment, and lens to the African perspective.Frontiers in pharmacology · 2022Review
- Differential regulatory effect of progesterone on the proliferation and apoptosis of uterine leiomyoma tissue explants and primary leiomyoma cell cultures.JBRA assisted reproduction · 2021Article
- A network pharmacology approach to investigate the pharmacological effects of Guizhi Fuling Wan on uterine fibroids.Experimental and therapeutic medicine · 2017Article
- Signaling Pathways in Leiomyoma: Understanding Pathobiology and Implications for Therapy.Molecular medicine (Cambridge, Mass.) · 2015Review
- Influence of AKT on progesterone action in endometrial diseases.Biology of reproduction · 2014Review
- Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.Endocrine reviews · 2013Review
- Kaempferol Exhibits Progestogenic Effects in Ovariectomized Rats.Journal of steroids & hormonal scienceArticle
- Proceedings from the Third National Institutes of Health International Congress on Advances in Uterine Leiomyoma Research: comprehensive review, conference summary and future recommendations.Human reproduction updateArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution.
Funding
Abstract
Progesterone is a key hormone in the regulation of uterine function. In the normal physiological context, progesterone is primarily involved in remodeling of the endometrium and maintaining a quiescent myometrium. When pathologies of the uterus develop, specifically, endometrial cancer and uterine leiomyoma, response to progesterone is usually altered. Progesterone acts through mainly two isoforms of the progesterone receptor (PR), PRA and PRB which have been reported to exhibit different transcriptional activities. Studies examining the expression and function of the PRs in the normal endometrium and myometrium as well as in endometrial cancer and uterine leiomyoma are summarized here. The clinical use of progestins and the transcriptional activity of the PR on genes specific to endometrial cancer and leiomyoma are described. An increased understanding of the differential expression of PRs and response to progesterone in these two diseases is critical in order to develop more efficient and targeted therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.