ArticleVeterinary research
Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions.
Article in Veterinary research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Silent Propagation of Classical Scrapie Prions in Homozygous KEmerging infectious diseases · 2025Article
- Evaluation of the application of Slovenia to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2024Article
- Evaluation of the application of the Czech Republic to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2023Article
- Strain Typing of Classical Scrapie and Bovine Spongiform Encephalopathy (BSE) by Using Ovine PrP (ARQ/ARQ) Overexpressing Transgenic Mice.International journal of molecular sciences · 2022Article
- Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases.Animals : an open access journal from MDPI · 2021Review
- Formation of distinct prion protein amyloid fibrils under identical experimental conditions.Scientific reports · 2020Article
- Classical Scrapie Did Not Re-occur in Goats After Cleaning and Disinfection of the Farm Premises.Frontiers in veterinary science · 2020Article
- The Scrapie Prevalence in a Goat Herd Is Underestimated by Using a Rapid Diagnostic Test.Frontiers in bioengineering and biotechnology · 2020Article
- Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPBMC veterinary research · 2019Article
- Article
- Protecting effect of PrP codons M142 and K222 in goats orally challenged with bovine spongiform encephalopathy prions.Veterinary research · 2017Article
- Codon 141 polymorphisms of the ovine prion protein gene affect the phenotype of classical scrapie transmitted from goats to sheep.BMC veterinary research · 2017Article
- Article
- Genetic, histochemical and biochemical studies on goat TSE cases from Cyprus.Veterinary research · 2016Article
- Evidence of scrapie transmission to sheep via goat milk.BMC veterinary research · 2016Article
- Prenatal transmission of scrapie in sheep and goats: A case study for veterinary public health.Open veterinary journal · 2016Review
- Evaluation of the application of Denmark to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2015Article
- Evaluation of the application of Finland to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2015Article
- Evaluation of the application of Sweden to be recognised as having a negligible risk of classical scrapie.EFSA journal. European Food Safety Authority · 2015Article
- The placenta shed from goats with classical scrapie is infectious to goat kids and lambs.The Journal of general virology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After detection of a high prevalence of scrapie in a large dairy goat herd, 72 infected animals were examined by immunohistochemistry with prion protein (PrP) antibody Bar224 to study the pathogenesis of the infection. Tissues examined included the brain and thoracic spinal cord (TSC), a wide selection of lymphoreticular system (LRS) tissues, the distal ileum and its enteric nervous system (ENS), and other organs, including the mammary gland. The whole open reading frame of the PRNP gene was sequenced and antibodies to caprine arthritis-encephalitis virus (CAEV) infection were determined. Unexpectedly, accumulation of disease-associated PrP (PrPd) in the brain was more frequent in methionine carriers at codon 142 (24/32, 75.0%) than amongst isoleucine homozygotes (14/40, 35.0%). The latter, however, showed significantly greater amounts of brain PrPd than the former (average scores of 9.3 and 3.0, respectively). A significant proportion of the 38 goats that were positive in brain were negative in the ENS (44.7%) or in the TSC (39.5%). These results, together with the early and consistent involvement of the circumventricular organs and the hypothalamus, point towards a significant contribution of the haematogenous route in the process of neuroinvasion. Chronic enteritis was observed in 98 of the 200 goats examined, with no association with either scrapie infection or presence of PrPd in the gut. Lymphoproliferative interstitial mastitis was observed in 13/31 CAEV-positive and scrapie-infected goats; PrPd in the mammary gland was detected in five of those 13 goats, suggesting a possible contribution of CAEV infection in scrapie transmission via milk.
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Registered trials
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