ArticleMicroscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada2010
Nanoscale X-ray microscopic imaging of mammalian mineralized tissue.
Article in Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 84 citations in OpenAlex.
- Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants.Bioactive materials · 2023Article
- Ultrathin, Transparent, and High Density Perovskite Scintillator Film for High Resolution X-Ray Microscopic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Next-generation imaging of the skeletal system and its blood supply.Nature reviews. Rheumatology · 2019Review
- Unsupervised Data Mining in nanoscale X-ray Spectro-Microscopic Study of NdFeB Magnet.Scientific reports · 2016Article
- 3D X-ray ultra-microscopy of bone tissue.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Potentially biogenic carbon preserved in a 4.1 billion-year-old zircon.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Morphological Characterisation of Unstained and Intact Tissue Micro-architecture by X-ray Computed Micro- and Nano-Tomography.Scientific reports · 2015Article
- Strain amplification analysis of an osteocyte under static and cyclic loading: a finite element study.BioMed research international · 2015Article
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- Micro- and nano-CT for the study of bone ultrastructure.Current osteoporosis reports · 2014Review
- Five-dimensional visualization of phase transition in BiNiOApplied physics letters · 2014Article
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- Talbot-defocus multiscan tomography using the synchrotron X-ray microscope to study the lacuno-canalicular network in mouse bone.Biomedical optics express · 2013Article
- Review
- Mesoscale phase distribution in single particles of LiFePOChemistry of materials : a publication of the American Chemical Society · 2013Article
- Nanoscale examination of microdamage in sheep cortical bone using synchrotron radiation transmission x-ray microscopy.PloS one · 2013Article
- TXM-Wizard: a program for advanced data collection and evaluation in full-field transmission X-ray microscopy.Journal of synchrotron radiation · 2012Article
- Article
- Article
- Three-dimensional imaging of chemical phase transformations at the nanoscale with full-field transmission X-ray microscopy.Journal of synchrotron radiation · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 9 institutions in 3 countries.
Funding
Abstract
A novel hard transmission X-ray microscope (TXM) at the Stanford Synchrotron Radiation Lightsource operating from 5 to 15 keV X-ray energy with 14 to 30 microm2 field of view has been used for high-resolution (30-40 nm) imaging and density quantification of mineralized tissue. TXM is uniquely suited for imaging of internal cellular structures and networks in mammalian mineralized tissues using relatively thick (50 microm), untreated samples that preserve tissue micro- and nanostructure. To test this method we performed Zernike phase contrast and absorption contrast imaging of mouse cancellous bone prepared under different conditions of in vivo loading, fixation, and contrast agents. In addition, the three-dimensional structure was examined using tomography. Individual osteocytic lacunae were observed embedded within trabeculae in cancellous bone. Extensive canalicular networks were evident and included processes with diameters near the 30-40 nm instrument resolution that have not been reported previously. Trabecular density was quantified relative to rod-like crystalline apatite, and rod-like trabecular struts were found to have 51-54% of pure crystal density and plate-like areas had 44-53% of crystal density. The nanometer resolution of TXM enables future studies for visualization and quantification of ultrastructural changes in bone tissue resulting from osteoporosis, dental disease, and other pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.