ArticleBMC cancer2010
Growth delay of human bladder cancer cells by Prostate Stem Cell Antigen downregulation is associated with activation of immune signaling pathways.
Article in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.Nature genetics · 2012Pooled it
- Identification of novel protein markers and therapeutic targets for common urological cancers by integrating large-scale human plasma proteome with the genome.Scientific reports · 2026Article
- Significance of PSCA as a novel prognostic marker and therapeutic target for cancer.Cancer cell international · 2024Review
- SNP rs2920280 inDiagnostics (Basel, Switzerland) · 2022Article
- A single nucleotide polymorphism inJournal of clinical biochemistry and nutrition · 2021Article
- Downregulation of PSCA promotes gastric cancer proliferation and is related to poor prognosis.Journal of Cancer · 2020Article
- PSCArs2294008 T polymorphism increases the risk of bladder cancer in Bai, Dai, and Han ethnicity in China and a potential mechanism.Genes & genomics · 2018Article
- Decrease inOncotarget · 2018Article
- Association of high-evidence gastric cancer susceptibility loci and somatic gene expression levels with survival.Carcinogenesis · 2017Article
- Exploratory investigation of PSCA-protein expression in primary breast cancer patients reveals a link to HER2/neu overexpression.Oncotarget · 2017Article
- Single-nucleotide polymorphisms in PSCA and the risk of breast cancer in a Chinese population.Oncotarget · 2016Article
- PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.Scientific reports · 2016Article
- Knockdown of PSCA induces EMT and decreases metastatic potentials of the human prostate cancer DU145 cells.Cancer cell international · 2016Article
- Targeted therapies in bladder cancer: an overview of in vivo research.Nature reviews. Urology · 2015Review
- Association between PSCA mRNA expression levels and rs2294008 polymorphism in transitional cell cancer of the bladder.Oncology letters · 2015Article
- Prostate stem cell antigen variation rs2294008 associated with the risk of bladder cancer.International journal of clinical and experimental medicine · 2015Article
- Association of a common genetic variant in prostate stem cell antigen with cancer risk.Archives of medical science : AMS · 2014Review
- Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population.Cancer science · 2014Article
- Targeted therapies in urothelial carcinoma.Current opinion in oncology · 2014Review
- Genetic variant as a selection marker for anti-prostate stem cell antigen immunotherapy of bladder cancer.Journal of the National Cancer Institute · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProstate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI) anchored protein expressed not only in prostate but also in pancreas and bladder cancer as shown by immunohistochemistry and mRNA analysis. It has been targeted by monoclonal antibodies in preclinical animal models and more recently in a clinical trial in prostate cancer patients. The biological role played in tumor growth is presently unknown. In this report we have characterized the contribution of PSCA expression to tumor growth.
methodsA bladder cell line was engineered to express a doxycycline (dox) regulated shRNA against PSCA. To shed light on the PSCA biological role in tumor growth, microarray analysis was carried out as a function of PSCA expression. Expression of gene set of interest was further analyzed by qPCR
resultsDown regulation of the PSCA expression was associated with reduced cell proliferation in vitro and in vivo. Mice bearing subcutaneous tumors showed a reduced tumor growth upon treatment with dox, which effectively induced shRNA against PSCA as revealed by GFP expression. Pathway analysis of deregulated genes suggests a statistical significant association between PSCA downregulation and activation of genes downstream of the IFNalpha/beta receptor.
conclusionsThese experiments established for the first time a correlation between the level of PSCA expression and tumor growth and suggest a role of PSCA in counteracting the natural immune response.
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