ArticleBMC endocrine disorders2010
Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control.
Article in BMC endocrine disorders, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
- An assessment of the functional state of endothelial colony forming cells from patients with diabetes mellitus and chronic limb threatening ischemia.Stem cells translational medicine · 2025Article
- Establishment and external validation of an early warning model of diabetic peripheral neuropathy based on random forest and logistic regression.BMC endocrine disorders · 2024Article
- Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke.Scientific reports · 2023Article
- Endothelial progenitor cells as biomarkers of diabetes-related cardiovascular complications.Stem cell research & therapy · 2023Review
- Repurposing Metformin for Vascular Disease.Current medicinal chemistry · 2023Review
- The effects of oralHeliyon · 2021Article
- Endothelial Cells as Tools to Model Tissue Microenvironment in Hypoxia-Dependent Pathologies.International journal of molecular sciences · 2021Review
- Angiogenic Factor AGGF1-Primed Endothelial Progenitor Cells Repair Vascular Defect in Diabetic Mice.Diabetes · 2019Article
- Article
- Severe Type 2 Diabetes Induces Reversible Modifications of Endothelial Progenitor Cells Which are Ameliorate by Glycemic Control.International journal of stem cells · 2016Article
- Vascular repair strategies in type 2 diabetes: novel insights.Cardiovascular diagnosis and therapy · 2015Review
- Determination of Early and Late Endothelial Progenitor Cells in Peripheral Circulation and Their Clinical Association with Coronary Artery Disease.International journal of vascular medicine · 2015Article
- Autologous Stem Cell Therapy: How Aging and Chronic Diseases Affect Stem and Progenitor Cells.BioResearch open access · 2015Review
- Reduced levels of circulating endothelial progenitor cells in acute myocardial infarction patients with diabetes or pre-diabetes: accompanying the glycemic continuum.Cardiovascular diabetology · 2014Article
- Ultrasound microbubble-mediated delivery of integrin-linked kinase gene improves endothelial progenitor cells dysfunction in pre-eclampsia.DNA and cell biology · 2014Article
- Article
- Patients with an HbA1c in the prediabetic and diabetic range have higher numbers of circulating cells with osteogenic and endothelial progenitor cell markers.The Journal of clinical endocrinology and metabolism · 2012Article
- Apoptosis of endothelial progenitor cells in a metabolic syndrome experimental model.Journal of cardiovascular disease research · 2012Article
- Application of anodized titanium for enhanced recruitment of endothelial progenitor cells.Nanoscale research letters · 2012Article
- Impact of glycemic control on circulating endothelial progenitor cells and arterial stiffness in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial progenitor cells (EPCs) play an important role in vascular repair and a decrease in the number of EPCs is observed in type 2 diabetes. However, there is no report on the change of EPCs after glycemic control. This study therefore aimed to investigate the EPC number and function in patients with good and poor glycemic control.
methodsThe number of EPCs was studied using flow cytometry by co-expression of CD34 and VEGFR2. The EPCs were cultured and characterized by the expression of UEA-I, CD34, VEGFR2, vWF and Dil-Ac-LDL engulfment, as well as the ability to form capillary-like structures. An in vitro study on the effect of hyperglycemia on the proliferation and viability of the cultured EPCs was also performed.
resultsThe number of EPCs in type 2 diabetes was significantly decreased compared with healthy controls and there was an inverse correlation between the EPC numbers and plasma glucose, as well as HbA1C. The number and function of EPCs in patients with good glycemic control were recovered compared with those with poor glycemic control. When glucose was supplemented in the culture in vitro, there was a negative effect on the proliferation and viability of EPCs, in a dose-dependent manner, whereas the enhancement of apoptosis was observed.
conclusionThere was EPC dysfunction in type 2 diabetes which might be improved by strict glycemic control. However, the circulating EPC number and proliferative function in patients with good glycemic control did not reach the level in healthy controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.