ArticleAnnals of clinical microbiology and antimicrobials2010
Antimicrobial resistance in equine faecal Escherichia coli isolates from North West England.
Article in Annals of clinical microbiology and antimicrobials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Zoonotic Diseases from Horses: A Systematic Review.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2020Pooled it
- Antimicrobial Resistance Phenotypes and Genotypes ofAntibiotics (Basel, Switzerland) · 2025Article
- Knowledge levels regarding antibiotics and their use among horse owners in the State of Rio Grande do Norte, Brazil.Brazilian journal of veterinary medicine · 2025Article
- Impacts of Domestication and Veterinary Treatment on Mobile Genetic Elements and Resistance Genes in Equine Fecal Bacteria.Applied and environmental microbiology · 2023Article
- Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids.Antibiotics (Basel, Switzerland) · 2023Review
- Antibiotic Resistance in Bacteria-A Review.Antibiotics (Basel, Switzerland) · 2022Review
- Characterisation of and risk factors for extended-spectrum β-lactamase producing Enterobacterales (ESBL-E) in an equine hospital with a special reference to an outbreak caused by Klebsiella pneumoniae ST307:CTX-M-1.Acta veterinaria Scandinavica · 2022Article
- Extended-spectrum beta-lactamase (ESBL) producing and multidrug-resistantJournal of food science and technology · 2021Article
- Antibiotic Resistance in Shiga ToxigenicAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Antibiotic prescription practices and opinions regarding antimicrobial resistance among veterinarians in Kentucky, USA.PloS one · 2021Article
- Biogenic Synthesis of ZnO Nanoparticles and Its Potential Use as Antimicrobial Agent Against Multidrug-Resistant Pathogens.Current microbiology · 2020Article
- Article
- Pathotypes and Antimicrobial Susceptibility ofAnimals : an open access journal from MDPI · 2020Article
- Putative Protein Biomarkers ofBiology · 2020Article
- Extended-Spectrum β-lactamase-ProducingAnimals : an open access journal from MDPI · 2020Article
- Pathotyping and Antibiotic Resistance Profiling ofBioMed research international · 2020Article
- Antimicrobial resistance profiles and phylogenetic groups ofJournal of equine science · 2020Article
- Extended-spectrum β-lactamase-producingJournal of equine science · 2019Article
- Antimicrobial resistance and the presence of extended-spectrum beta-lactamase genes in Escherichia coli isolated from the environment of horse riding centers.Environmental science and pollution research international · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEscherichia coli isolates of equine faecal origin were investigated for antibiotic resistance, resistance genes and their ability to perform horizontal transfer.
methodsIn total, 264 faecal samples were collected from 138 horses in hospital and community livery premises in northwest England, yielding 296 resistant E. coli isolates. Isolates were tested for susceptibility to antimicrobial drugs by disc diffusion and agar dilution methods in order to determine minimum inhibitory concentrations (MIC). PCR amplification was used to detect genes conferring resistance to: ampicillin (TEM and SHV beta-lactamase), chloramphenicol (catI, catII, catIII and cml), tetracycline (tetA, tetB, tetC, tetD, tet E and tetG), and trimethoprim (dfrA1, dfrA9, dfrA12, dfrA13, dfr7, and dfr17).
resultsThe proportion of antibiotic resistant isolates, and multidrug resistant isolates (MDR) was significantly higher in hospital samples compared to livery samples (MDR: 48% of hospital isolates; 12% of livery isolates, p < 0.001). Resistance to ciprofloxacin and florfenicol were identified mostly within the MDR phenotypes. Resistance genes included dfr, TEM beta-lactamase, tet and cat, conferring resistance to trimethoprim, ampicillin, tetracycline and chloramphenicol, respectively. Within each antimicrobial resistance group, these genes occurred at frequencies of 93% (260/279), 91%, 86.8% and 73.5%, respectively; with 115/296 (38.8%) found to be MDR isolates. Conjugation experiments were performed on selected isolates and MDR phenotypes were readily transferred.
conclusionsOur findings demonstrate that E. coli of equine faecal origin are commonly resistant to antibiotics used in human and veterinary medicine. Furthermore, our results suggest that most antibiotic resistance observed in equine E. coli is encoded by well-known and well-characterized resistant genes common to E. coli from man and domestic animals. These data support the ongoing concern about antimicrobial resistance, MDR, antimicrobial use in veterinary medicine and the zoonotic risk that horses could potentially pose to public health.
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