ArticlePsychophysiology2010
Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: data from the COGS study.
Article in Psychophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Mapping 60 Years of Psychophysiology: A Bibliometric Analysis of Journal Performance, Authorship Trends, and Thematic Evolution.Psychophysiology · 2025Review
- Eye Movement Abnormalities Can Distinguish First-Episode Schizophrenia, Chronic Schizophrenia, and Prodromal Patients From Healthy Controls.Schizophrenia bulletin open · 2023Article
- Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2).Psychological medicine · 2022Article
- Altered Effective Connectivity within an Oculomotor Control Network in Unaffected Relatives of Individuals with Schizophrenia.Brain sciences · 2021Article
- Endophenotypes in Schizophrenia: Digging Deeper to Identify Genetic Mechanisms.Journal of psychiatry and brain science · 2019Article
- Alterations in intrinsic fronto-thalamo-parietal connectivity are associated with cognitive control deficits in psychotic disorders.Human brain mapping · 2019Article
- Recent Advances in the Genetics of Schizophrenia.Molecular neuropsychiatry · 2018Review
- The influence of schizotypal traits on attention under high perceptual load.Schizophrenia research. Cognition · 2018Article
- The Stochastic Early Reaction, Inhibition, and late Action (SERIA) model for antisaccades.PLoS computational biology · 2017Article
- Behavioural and computational varieties of response inhibition in eye movements.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- Prioritizing schizophrenia endophenotypes for future genetic studies: An example using data from the COGS-1 family study.Schizophrenia research · 2016Article
- Pursuit eye movements as an intermediate phenotype across psychotic disorders: Evidence from the B-SNIP study.Schizophrenia research · 2015Article
- Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.Schizophrenia research · 2015Review
- Factor structure and heritability of endophenotypes in schizophrenia: findings from the Consortium on the Genetics of Schizophrenia (COGS-1).Schizophrenia research · 2015Article
- Robust differences in antisaccade performance exist between COGS schizophrenia cases and controls regardless of recruitment strategies.Schizophrenia research · 2015Article
- California Verbal Learning Test-II performance in schizophrenia as a function of ascertainment strategy: comparing the first and second phases of the Consortium on the Genetics of Schizophrenia (COGS).Schizophrenia research · 2015Article
- Impaired top-down modulation of saccadic latencies in patients with schizophrenia but not in first-degree relatives.Frontiers in behavioral neuroscience · 2015Article
- Elevated antisaccade error rate as an intermediate phenotype for psychosis across diagnostic categories.Schizophrenia bulletin · 2014Article
- Is there an association between advanced paternal age and endophenotype deficit levels in schizophrenia?PloS one · 2014Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
The antisaccade task is a widely used technique to measure failure of inhibition, an important cause of cognitive and clinical abnormalities found in schizophrenia. Although antisaccade performance, which reflects the ability to inhibit prepotent responses, is a putative schizophrenia endophenotype, researchers have not consistently reported the expected differences between first-degree relatives and comparison groups. Schizophrenia participants (n=219) from the large Consortium on the Genetics of Schizophrenia (COGS) sample (n=1078) demonstrated significant deficits on an overlap version of the antisaccade task compared to their first-degree relatives (n=443) and community comparison subjects (CCS; n=416). Although mean antisaccade performance of first-degree relatives was intermediate between schizophrenia participants and CCS, a linear mixed-effects model adjusting for group, site, age, and gender found no significant performance differences between the first-degree relatives and CCS. However, admixture analyses showed that two components best explained the distributions in all three groups, suggesting two distinct doses of an etiological factor. Given the significant heritability of antisaccade performance, the effects of a genetic polymorphism is one possible explanation of our results.
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