Evidence map›Paper›PMID 20374221›Full record

ArticleAlcoholism, clinical and experimental research2010

Advancing alcohol biomarkers research.

Cynthia F Bearer, Shannon M Bailey, Jan B Hoek

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Development and validation of a composite score for excessive alcohol use screening.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016
    Article
  8. Article
  9. Novel serum biomarkers for detection of excessive alcohol use.Alcoholism, clinical and experimental research · 2015
    Article
  10. Article
  11. Proteomic approaches and identification of novel therapeutic targets for alcoholism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014
    Review
  12. Article
  13. Protein biomarkers of alcohol abuse.Expert review of proteomics · 2012
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cynthia F BearerDivision of Neonatology, Department of Pediatrics, University of Maryland Hospital for Children, Baltimore, Maryland, USA.
Shannon M Bailey
Jan B Hoek

Funding

Study of Prevalent Neurotoxicants in ChildrenP01ES011261 · NIEHS · CINCINNATI CHILDRENS HOSP MED CTR · PI LANPHEAR, BRUCE P · 2001 to 2006
$6.4M
The Role of Lipid Rafts in Fetal Alcohol Spectrum DisorderR01AA016398 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BEARER, CYNTHIA FRANCES · 2007 to 2011
$1.5M
NIAAA NIH HHS R01 AA016398NIEHS NIH HHS P01 ES011261
6 · The paper itself

Abstract

Biomarkers to detect past alcohol use and identify alcohol-related diseases have long been pursued as important tools for research into alcohol use disorders as well as for clinical and treatment applications and other settings. The National Institute on Alcohol Abuse and Alcoholism (NIAAA) sponsored a workshop titled "Workshop on Biomarkers for Alcohol-Induced Disorders" in June 2008. The intent of this workshop was to review and discuss recent progress in the development and implementation of biomarkers for alcohol use and alcohol-related disorders with a goal to formulate a set of recommendations to use to stimulate and advance research progress in this critical area of alcoholism research. Presentations at this workshop reviewed the current status of alcohol biomarkers, providing a summary of the history of biomarkers and the major goals of alcohol biomarker research. Moreover, presentations provided a comprehensive overview of the current status of several well-recognized biomarkers of alcohol use, a summary of recent studies to characterize novel biomarkers and their validation, along with perspectives and experiences from other NIH institutes and from other federal agencies and industry, related to regulatory issues. Following these presentations, a panel discussion focused on a set of issues presented by the organizers of this workshop. These discussion points addressed: (i) issues related to strategies to be adopted to stimulate biomarker discovery and application, (ii) the relevance of animal studies in biomarker development and the status of biomarkers in basic science studies, and (iii) issues related to the opportunities for clinical and commercial applications. This article summarizes these perspectives and highlights topics that constituted the basis for recommendations to enhance alcohol biomarker research.

Indexed as

Alcohol DrinkingAlcohol-Related DisordersAnimalsBiomarkersBiomedical ResearchHumansModels, AnimalPrognosisSensitivity and SpecificityBiomarkers

Identifiers

PMID20374221
PMCPMC4196261

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.