ReviewAlcoholism, clinical and experimental research2010
Genetic and environmental influences on ethanol consumption: perspectives from preclinical research.
Review in Alcoholism, clinical and experimental research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice.Psychopharmacology · 2025Article
- Maternal Substance Use and Early-Life Adversity: Inducing Drug Dependence in Offspring, Interactions, Mechanisms, and Treatments.Addiction & health · 2024Review
- Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Article
- Impact of Prenatal Alcohol Exposure on the Development and Myocardium of Adult Mice: Morphometric Changes, Transcriptional Modulation of Genes Related to Cardiac Dysfunction, and Antioxidant Cardioprotection.Antioxidants (Basel, Switzerland) · 2023Article
- Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base.Substance abuse and rehabilitation · 2023Review
- Protective effects of isoflavones on alcoholic liver diseases: Computational approaches to investigate the inhibition of ALDH2 with isoflavone analogues.Frontiers in molecular biosciences · 2023Review
- Serotonin disruption at gestation alters expression of genes associated with serotonin synthesis and reuptake at weaning.Psychopharmacology · 2022Article
- Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice.Psychopharmacology · 2021Article
- Evidence for a Link Between Fkbp5/FKBP5, Early Life Social Relations and Alcohol Drinking in Young Adult Rats and Humans.Molecular neurobiology · 2017Article
- Rat animal models for screening medications to treat alcohol use disorders.Neuropharmacology · 2017Review
- A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.International review of neurobiology · 2016Review
- Effect of voluntary alcohol consumption on Maoa expression in the mesocorticolimbic brain of adult male rats previously exposed to prolonged maternal separation.Translational psychiatry · 2015Article
- Relationship between ethanol-induced activity and anxiolysis in the open field, elevated plus maze, light-dark box, and ethanol intake in adolescent rats.Behavioural brain research · 2014Article
- Alcoholism and liver disease in Mexico: genetic and environmental factors.World journal of gastroenterology · 2013Review
- Is the rodent maternal separation model a valid and effective model for studies on the early-life impact on ethanol consumption?Psychopharmacology · 2013Review
- μ-Opioid blockade reduces ethanol effects on intake and behavior of the infant rat during short-term but not long-term social isolation.Pharmacology, biochemistry, and behavior · 2013Article
- Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.Pharmacology, biochemistry, and behavior · 2012Review
- Ethanol metabolism and osmolarity modify behavioral responses to ethanol in C. elegans.Alcoholism, clinical and experimental research · 2012Article
- Ethanol concentration-dependent effects and the role of stress on ethanol drinking in corticotropin-releasing factor type 1 and double type 1 and 2 receptor knockout mice.Psychopharmacology · 2011Article
- ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications.Pharmacology & therapeutics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundAlcohol use disorders (abuse and dependence, AUD) are multifactorial phenomena, depending on the interplay of environmental and genetic variables.
methodThis review describes current developments in animal research that may help (a) develop gene therapies for the treatment of alcoholism, (b) understand the permissive role of stress on ethanol intake, and (c) elucidate why exposure to ethanol early in life is associated with a greater risk of AUD.
resultsThe polymorphisms found in liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) affect the elimination of ethanol and the susceptibility to ethanol intake. A highly active ADH protects against alcoholism, an effect related to a presteady state burst in arterial acetaldehyde. Social stressors, such as repeated early maternal separation or social defeat, exert a permissive effect on ethanol intake, perhaps by altering the normal development of the hypothalamic-pituitary-adrenal axis. Ethanol exposure during gestation, infancy, or adolescence increases the likelihood of AUD later in life. Early perception of ethanol's positive and negative (anti-anxiety) reinforcing effects may play a role in this phenomenon.
conclusionsThe review underscores the advantages of using preclinical animal models of AUD and highlights points of intersection between the topics to help design a more integrated approach for the study of alcohol-related problems.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.