ArticleAnalytical chemistry2010
High speed nonlinear interferometric vibrational analysis of lipids by spectral decomposition.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- On the importance of simultaneous label-free multimodal nonlinear optical imaging for biomedical applications.APL photonics · 2025Article
- Tracking the formation and degradation of fatty-acid-accumulated mitochondria using label-free chemical imaging.Scientific reports · 2021Article
- Article
- Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography.Optics express · 2016Article
- Biological imaging with coherent Raman scattering microscopy: a tutorial.Journal of biomedical optics · 2014Article
- Label-free quantitative imaging of cholesterol in intact tissues by hyperspectral stimulated Raman scattering microscopy.Angewandte Chemie (International ed. in English) · 2013Article
- The Gold Nanorod-Biology Interface: From Proteins to Cells to Tissue.Current physical chemistry · 2013Article
- Quantitative vibrational imaging by hyperspectral stimulated Raman scattering microscopy and multivariate curve resolution analysis.Analytical chemistry · 2013Article
- Biomolecular imaging with coherent nonlinear vibrational microscopy.Annual review of physical chemistry · 2013Review
- Characterization of cholesterol crystals in atherosclerotic plaques using stimulated Raman scattering and second-harmonic generation microscopy.Biophysical journal · 2012Article
- Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging.Journal of lipid research · 2011Article
- Nonlinear interferometric vibrational imaging for fast label-free visualization of molecular domains in skin.Analytical and bioanalytical chemistry · 2011Article
- Coherent anti-Stokes Raman scattering hyperspectral tissue imaging with a wavelength-swept system.Biomedical optics express · 2011Article
- Picosecond spectral coherent anti-Stokes Raman scattering imaging with principal component analysis of meibomian glands.Journal of biomedical optics · 2011Article
- Hyperspectral coherent anti-Stokes Raman scattering microscopy imaging through turbid medium.Journal of biomedical optics · 2011Article
- Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing.Journal of biomedical optics · 2011Article
- Molecular histopathology by spectrally reconstructed nonlinear interferometric vibrational imaging.Cancer research · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Unlike other CARS-based (coherent anti-Stokes Raman scattering) spectroscopy techniques, nonlinear interferometric vibrational spectroscopy (NIVS) is linear in analyte concentration and has a Raman line shape free of nonresonant background distortions. We use spontaneous Raman scattering as a high accuracy benchmark for NIVS. As a challenging comparison, we examine spectra in the CH stretching region of six lipid samples. Singular value decomposition and reference to an independent chemical assay are used to directly compare NIVS and spontaneous Raman scattering. We demonstrate that NIVS can determine the relative degree of unsaturation in six different lipid samples as accurately as spontaneous Raman spectroscopy, but 200 times faster. A skin tissue sample is mapped out to demonstrate quantitative lipid-protein differentiation with spatial resolution.
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