ArticleAnalytical chemistry2010
Particle focusing in staged inertial microfluidic devices for flow cytometry.
Article in Analytical chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 220 citations in OpenAlex.
- Ridge-assisted micro positioning of cells in a channel.Science advances · 2026Article
- Spatial Encoding with Amplitude Modulation in Serial Flow Cytometry.Sensors (Basel, Switzerland) · 2026Article
- Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel.bioRxiv : the preprint server for biology · 2025Article
- Essential Fluidics for a Flow Cytometer.Current protocols · 2024Article
- Deterministic Single-Cell Encapsulation in PEG Norbornene Microgels for Promoting Anti-Inflammatory Response and Therapeutic Delivery of Mesenchymal Stromal Cells.Advanced healthcare materials · 2024Article
- Deformability-Based Isolation of Circulating Tumor Cells in Spiral Microchannels.Micromachines · 2023Article
- Dean-Flow Affected Lateral Focusing and Separation of Particles and Cells in Periodically Inhomogeneous Microfluidic Channels.Sensors (Basel, Switzerland) · 2023Article
- Sheathless inertial particle focusing methods within microfluidic devices: a review.Frontiers in bioengineering and biotechnology · 2023Review
- Numerical investigation of the dynamics of a rigid spherical particle in a vortical cross-slot flow at moderate inertia.Microsystems & nanoengineering · 2023Article
- Patterns of bacterial motility in microfluidics-confining environments.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- An overview of functional nanoparticles as novel emerging antiviral therapeutic agents.Materials science & engineering. C, Materials for biological applications · 2020Review
- Flow Homogenization Enables a Massively Parallel Fluidic Design for High-throughput and Multiplexed Cell Isolation.Advanced materials technologies · 2020Article
- Viscoelastic second normal stress difference dominated multiple-stream particle focusing in microfluidic channels.Applied physics letters · 2019Article
- Label-free microfluidic sorting of microparticles.APL bioengineering · 2019Review
- New insights into the physics of inertial microfluidics in curved microchannels. I. Relaxing the fixed inflection point assumption.Biomicrofluidics · 2019Article
- Cell Cytometry: Review and Perspective on Biotechnological Advances.Frontiers in bioengineering and biotechnology · 2019Review
- Comparative cytocompatibility of multiple candidate cell types to photoencapsulation in PEGNB/PEGDA macroscale or microscale hydrogels.Biomedical materials (Bristol, England) · 2018Article
- Standing Surface Acoustic Wave (SSAW)-Based Fluorescence-Activated Cell Sorter.Small (Weinheim an der Bergstrasse, Germany) · 2018Article
- High-throughput cell focusing and separation via acoustofluidic tweezers.Lab on a chip · 2018Article
- Progress of Inertial Microfluidics in Principle and Application.Sensors (Basel, Switzerland) · 2018Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Microfluidic inertial focusing has been demonstrated to be an effective method for passively positioning microparticles and cells without the assistance of sheath fluid. Because inertial focusing produces well-defined lateral equilibrium particle positions in addition to highly regulated interparticle spacing, its value in flow cytometry has been suggested. Particle focusing occurs in straight channels and can be manipulated through cross sectional channel geometry by the introduction of curvature. Here, we present a staged channel design consisting of both curved and straight sections that combine to order particles into a single streamline with longitudinal spacing. We have evaluated the performance of these staged inertial focusing channels using standard flow cytometry methods that make use of calibration microspheres. Our analysis has determined the measurement precision and resolution, as a function of flow velocity and particle concentration that is provided by these channels. These devices were found to operate with increasing effectiveness at higher flow rates and particle concentrations, within the examined ranges, which is ideal for high throughput analysis. Further, the prototype flow cytometer equipped with an inertial focusing microchannel matched the resolution provided by a commercial hydrodynamic focusing flow cytometer. Most notably, our analysis indicates that the inertial focusing channels virtually eliminated particle coincidence at the analysis point. These properties suggest a potentially significant role for inertial focusing in the development of inexpensive flow cytometry-based diagnostics and in applications requiring the analysis of high particle concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.