ReviewDialogues in clinical neuroscience2010
Epigenetic approaches to psychiatric disorders.
Review in Dialogues in clinical neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Risk of Disruptive Behavioral Disorders in the Offspring of Parents with Severe Psychiatric Disorders.Child psychiatry and human development · 2021Pooled it
- Sleep Problems and Workplace Violence: A Systematic Review and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Epigenetics of generalized internet use disorder including data on overuse of social media: a closer look at the SLC6A4, NR3C1 and OXT genes.BMC psychiatry · 2026Article
- Unveiling the mechanistic nexus: how micronutrient enrichment shapes brain function, and cognitive health.Frontiers in molecular biosciences · 2025Review
- Molecular signature of cadmium-mediated neurodevelopmental disorders in prenatal to postnatal stages.EXCLI journal · 2025Review
- Article
- Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet.International journal of molecular sciences · 2024Review
- Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia.Journal of personalized medicine · 2023Article
- Nutrition, Epigenetics, and Major Depressive Disorder: Understanding the Connection.Frontiers in nutrition · 2022Review
- Epigenetic Mechanism of Early Life Stress-Induced Depression: Focus on the Neurotransmitter Systems.Frontiers in cell and developmental biology · 2022Review
- Risk factors for obsessive-compulsive symptoms. Follow-up of a community-based youth cohort.European child & adolescent psychiatry · 2021Article
- Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics.International review of neurobiology · 2021Article
- Prenatal stress induced chromatin remodeling and risk of psychopathology in adulthood.International review of neurobiology · 2021Article
- Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes.Brain, behavior, and immunity · 2020Article
- Methylome profiling of young adults with depression supports a link with immune response and psoriasis.Clinical epigenetics · 2020Observational
- Differential DNA methylation following chemotherapy for breast cancer is associated with lack of memory improvement at one year.Epigenetics · 2020Article
- Cutting-edge genetics in obsessive-compulsive disorder.Faculty reviews · 2020Review
- Genetic variants in DNMT1 and the risk of cardiac autonomic neuropathy in women with type 1 diabetes.Journal of diabetes investigation · 2019Article
- Transgenerational epigenetic influences of paternal environmental exposures on brain function and predisposition to psychiatric disorders.Molecular psychiatry · 2019Review
- DNA methylation correlates of PTSD: Recent findings and technical challenges.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Psychiatric diseases place a tremendous burden on affected individuals, their caregivers, and the health care system. Although evidence exists for a strong inherited component to many of these conditions, dedicated efforts to identify DNA sequence-based causes have not been exceptionally productive, and very few pharmacologic treatment options are clinically available. Many features of psychiatric diseases are consistent with an epigenetic dysregulation, such as discordance of monozygotic twins, late age of onset, parent-of-origin and sex effects, and fluctuating disease course. In recent years, experimental technologies have significantly advanced, permitting in-depth studies of the epigenome and its role in maintenance of normal genomic functions, as well as disease etiopathogenesis. Here, we present an epigenetic explanation for many characteristics of psychiatric disease, review the current literature on the epigenetic mechanisms involved in major psychosis, Alzheimer's disease, and autism spectrum disorders, and describe some future directions in the field of psychiatric epigenomics.
Indexed as
Identifiers
20373664PMC3181944W1505238751What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.