ReviewJournal of cancer survivorship : research and practice2010
A review of exercise interventions to improve bone health in adult cancer survivors.
Review in Journal of cancer survivorship : research and practice, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02439112 (Early Initiated Individualized Physical Training in Newly Diagnosed Multiple Myeloma Patients; Effects on Physical Function, Physical Activity, Quality of Life, Pain, and Bone Disease.), which is not on this map. Cited by 30 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Initiated Individualized Physical Training in Newly Diagnosed Multiple Myeloma Patients; Effects on Physical Function, Physical Activity, Quality of Life, Pain, and Bone Disease.
Who cites it
30 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- The effect of exercise on bone mineral density in adult cancer survivors: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Physical activity for women with breast cancer after adjuvant therapy.The Cochrane database of systematic reviews · 2018Pooled it
- Exercise for improving bone health in women treated for stages I-III breast cancer: a systematic review and meta-analyses.Journal of cancer survivorship : research and practice · 2017Pooled it
- A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017).PM & R : the journal of injury, function, and rehabilitation · 2017Pooled it
- Trial
- Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema.Journal of cancer survivorship : research and practice · 2014Trial
- Musculoskeletal changes after 1 year of exercise in older breast cancer survivors.Journal of cancer survivorship : research and practice · 2014Trial
- Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Exercise effects on hip bone mineral density in older, post-menopausal breast cancer survivors are age dependent.Archives of osteoporosis · 2012Trial
- Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial.Breast cancer research and treatment · 2011Trial
- Fracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer.JAMA oncology · 2023Article
- Moving beyond Definitive Therapy: Increasing Physical Activity in Survivors of Cancers of the Head and Neck.Current oncology (Toronto, Ont.) · 2022Review
- Article
- Young cancer survivors have lower bone mineral density compared with healthy controls: a nationwide population-based study in Korea.Scientific reports · 2020Article
- Which factors can aid clinicians to identify a risk of pain during the following month in patients with bone metastases? A longitudinal analyses.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Efficacy of Complementary Therapies in the Quality of Life of Breast Cancer Survivors.Frontiers in oncology · 2017Review
- Combined aerobic and resistance training improves bone health of female cancer survivors.Bone reports · 2016Article
- Exercise Recommendations for the Management of Symptoms Clusters Resulting From Cancer and Cancer Treatments.Seminars in oncology nursing · 2016Review
- Juvenile competitive triathlete after cardiotoxic anthracycline therapy for Acute Myeloid Leukemia.Cardio-oncology (London, England) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCancer-treatment induced bone loss and associated fracture risk is a growing concern for cancer survivors. Exercise offers a non-pharmacologic strategy for preserving bone health during and after treatment, but only until recently has it been studied for its efficacy and safety in cancer survivors. The purpose of this review is to provide an early qualitative evaluation of exercise trials in adult cancer survivors with bone health as a primary or secondary endpoint.
methodsDatabases were searched for exercise trials in adult cancer survivors that reported data on bone health (bone mineral density (BMD) and/or bone remodeling markers) as an outcome measure and were published and indexed prior to January 1st, 2010. Data relevant to evaluation of study design, sample, exercise protocol, bone health assessment, statistical approach and findings were extracted, summarized and interpreted.
resultsEight trials were identified that met criteria for inclusion in the review. While most studies were conducted in breast cancer survivors, remaining study attributes including rigor, design, exercise program characteristics and length varied considerably across studies. Only three of the eight studies were controlled exercise trials with usual care control groups. Of these, two reported significant group x time interactions where aerobic exercise preserved BMD at the spine or whole body compared to losses in controls and none reported exercise benefits at the hip.
conclusionsThe recent emergence of exercise studies in cancer survivors with bone outcomes highlights the importance of this area of cancer survivorship. Collectively, the studies are limited in number and are too varied to warrant conclusions regarding the skeletal benefits of exercise during or after cancer treatment, though early results are encouraging and more rigorous study should follow.
Indexed as
Identifiers
20373041What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.