ArticlePharmaceutical research2010
PEG-poly(amino acid) block copolymer micelles for tunable drug release.
Article in Pharmaceutical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Polyamide/Poly(Amino Acid) Polymers for Drug Delivery.Journal of functional biomaterials · 2021Review
- Fabrication of Core Crosslinked Polymeric Micelles as Nanocarriers for Doxorubicin Delivery: Self-Assembly,Pharmaceutics · 2020Article
- Comparison of Dialysis- and Solvatofluorochromism-Based Methods to Determine Drug Release Rates from Polymer Nanoassemblies.Pharmaceutical research · 2017Article
- pH-Responsive Triblock Copolymeric Micelles Decorated with a Cell-Penetrating Peptide Provide Efficient Doxorubicin Delivery.Nanoscale research letters · 2016Article
- A Computational/Experimental Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors.Pharmaceutical research · 2016Article
- Particle-based technologies for osteoarthritis detection and therapy.Drug delivery and translational research · 2016Review
- Release, partitioning, and conjugation stability of doxorubicin in polymer micelles determined by mechanistic modeling.Pharmaceutical research · 2015Article
- Polymer nanoassemblies with solvato- and halo-fluorochromism for drug release monitoring and metastasis imaging.Therapeutic delivery · 2015Article
- Brushed block copolymer micelles with pH-sensitive pendant groups for controlled drug delivery.Pharmaceutical research · 2013Article
- Pharmaceutical differences between block copolymer self-assembled and cross-linked nanoassemblies as carriers for tunable drug release.Pharmaceutical research · 2013Article
- Drug release patterns and cytotoxicity of PEG-poly(aspartate) block copolymer micelles in cancer cells.Pharmaceutical research · 2012Article
- PEG-stabilized micellar system with positively charged polyester core for fast pH-responsive drug release.Pharmaceutical research · 2012Article
- Block copolymer micelles for controlled delivery of glycolytic enzyme inhibitors.Pharmaceutical research · 2012Article
- Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone.Pharmaceutical research · 2011Article
- Degradable Cross-Linked Nanoassemblies as Drug Carriers for Heat Shock Protein 90 Inhibitor 17-N-Allylamino-17-demethoxy-geldanamycin.Pharmaceuticals (Basel, Switzerland) · 2011Article
- Biomedical Applications of Biodegradable Polymers.Journal of polymer science. Part B, Polymer physics · 2011Article
- Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.International journal of nanomedicine · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo achieve tunable pH-dependent drug release in tumor tissues.
methodsPoly(ethylene glycol)-poly(aspartic acid) [PEG-p(Asp)] containing 12 kDa PEG and pAsp (5, 15, and 35 repeating units) were prepared. Hydrazide linkers with spacers [glycine (Gly) and 4-aminobenzoate (Abz)] were introduced to PEG-p(Asp), followed by drug conjugation [doxorubicin (DOX)]. The block copolymer-drug conjugates were either reconstituted or dialyzed in aqueous solutions to prepare micelles. Drug release patterns were observed under sink conditions at pH 5.0 and 7.4, 37°C, for 48 h.
resultsA collection of six block copolymers with different chain lengths and spacers was synthesized. Drug binding yields were 13-43.6%. The polymer-drug conjugates formed <50 nm polymer micelles irrespective of polymer compositions. Gly-introduced polymer micelles showed marginal change in particle size (40 ± 10 nm), while the size of Abz-micelles increased gradually from 10 to 40 nm as the polymer chain lengths increased. Drug release patterns of both Gly and Abz micelles were pH-dependent and tunable. The spacers appear to play a crucial role in controlling drug release and stability of polymer micelles in combination with block copolymer chain lengths.
conclusionA drug delivery platform for tunable drug release was successfully developed with polymer micelles possessing spacer-modified hydrazone drug-binding linkers.
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Registered trials
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